Fine-scale mapping of 8q24 locus identifies multiple independent risk variants for breast cancer.

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Authors

Shi, J
Zhang, Y
Zheng, W
Michailidou, K
Ghoussaini, M
Bolla, MK
Wang, Q
Dennis, J
Lush, M
Milne, RL
Shu, X-O
Beesley, J
Kar, S
Andrulis, IL
Anton-Culver, H
Arndt, V
Beckmann, MW
Zhao, Z
Guo, X
Benitez, J
Beeghly-Fadiel, A
Blot, W
Bogdanova, NV
Bojesen, SE
Brauch, H
Brenner, H
Brinton, L
Broeks, A
Brüning, T
Burwinkel, B
Cai, H
Canisius, S
Chang-Claude, J
Choi, J-Y
Couch, FJ
Cox, A
Cross, SS
Czene, K
Darabi, H
Devilee, P
Droit, A
Dork, T
Fasching, PA
Fletcher, O
Flyger, H
Fostira, F
Gaborieau, V
García-Closas, M
Giles, GG
Mervi Grip,
Guenel, P
Haiman, CA
Hamann, U
Hartman, M
Miao, H
Hollestelle, A
Hopper, JL
Hsiung, C-N
kConFab Investigators,
Ito, H
Jakubowska, A
Johnson, N
Torres, D
Kabisch, M
Kang, D
Khan, S
Knight, JA
Kosma, V-M
Lambrechts, D
Li, J
Lindblom, A
Lophatananon, A
Lubinski, J
Mannermaa, A
Manoukian, S
Le Marchand, L
Margolin, S
Marme, F
Matsuo, K
McLean, C
Meindl, A
Muir, K
Neuhausen, SL
Nevanlinna, H
Nord, S
Børresen-Dale, A-L
Olson, JE
Orr, N
van den Ouweland, AMW
Peterlongo, P
Putti, TC
Rudolph, A
Sangrajrang, S
Sawyer, EJ
Schmidt, MK
Schmutzler, RK
Shen, C-Y
Hou, M-F
Shrubsole, MJ
Southey, MC
Swerdlow, A
Teo, SH
Thienpont, B
Toland, AE
Tollenaar, RAEM
Tomlinson, I
Truong, T
Tseng, C-C
Wen, W
Winqvist, R
Wu, AH
Yip, CH
Zamora, PM
Zheng, Y
Floris, G
Cheng, C-Y
Hooning, MJ
Martens, JWM
Seynaeve, C
Kristensen, VN
Hall, P
Pharoah, PDP
Simard, J
Chenevix-Trench, G
Dunning, AM
Antoniou, AC
Easton, DF
Cai, Q
Long, J

Document Type

Journal Article

Date

2016-09-15

Date Accepted

2016-01-19

Abstract

Previous genome-wide association studies among women of European ancestry identified two independent breast cancer susceptibility loci represented by single nucleotide polymorphisms (SNPs) rs13281615 and rs11780156 at 8q24. A fine-mapping study across 2.06 Mb (chr8:127,561,724-129,624,067, hg19) in 55,540 breast cancer cases and 51,168 controls within the Breast Cancer Association Consortium was conducted. Three additional independent association signals in women of European ancestry, represented by rs35961416 (OR = 0.95, 95% CI = 0.93-0.97, conditional p = 5.8 × 10(-6) ), rs7815245 (OR = 0.94, 95% CI = 0.91-0.96, conditional p = 1.1 × 10(-6) ) and rs2033101 (OR = 1.05, 95% CI = 1.02-1.07, conditional p = 1.1 × 10(-4) ) were found. Integrative analysis using functional genomic data from the Roadmap Epigenomics, the Encyclopedia of DNA Elements project, the Cancer Genome Atlas and other public resources implied that SNPs rs7815245 in Signal 3, and rs1121948 in Signal 5 (in linkage disequilibrium with rs11780156, r(2)  = 0.77), were putatively functional variants for two of the five independent association signals. The results highlighted multiple 8q24 variants associated with breast cancer susceptibility in women of European ancestry.

Citation

International journal of cancer, 2016, 139 (6), pp. 1303 - 1317

Rights

Source Title

Publisher

WILEY

ISSN

0020-7136

eISSN

1097-0215

Research Team

Complex Trait Genetics
Functional Genetic Epidemiology
Aetiological Epidemiology

Notes