Tissue architecture in tumor initiation and progression.
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Embargo End Date
ICR Authors
Authors
Almagro, J
Messal, HA
Elosegui-Artola, A
van Rheenen, J
Behrens, A
Messal, HA
Elosegui-Artola, A
van Rheenen, J
Behrens, A
Document Type
Journal Article
Date
2022-06-01
Date Accepted
2022-02-17
Abstract
The 3D architecture of tissues bearing tumors impacts on the mechanical microenvironment of cancer, the accessibility of stromal cells, and the routes of invasion. A myriad of intrinsic and extrinsic forces exerted by the cancer cells, the host tissue, and the molecular and cellular microenvironment modulate the morphology of the tumor and its malignant potential through mechanical, biochemical, genetic, and epigenetic cues. Recent studies have investigated how tissue architecture influences cancer biology from tumor initiation and progression to distant metastatic seeding and response to therapy. With a focus on carcinoma, the most common type of cancer, this review discusses the latest discoveries on how tumor architecture is built and how tissue morphology affects the biology and progression of cancer cells.
Citation
Trends in cancer, 2022, 8 (6), pp. 494 - 505
Source Title
Publisher
CELL PRESS
ISSN
2405-8033
eISSN
2405-8025
2405-8025
2405-8025