A single-centre study evaluating a geriatric screening tool in oncology phase I trial patients.
Loading...
Embargo End Date
Authors
Van Zyl, M
Barell, A
Cooley, B
Hanwell, J
Parlak, J
Banerji, U
De Bono, J
Sharp, A
Lopez, J
Battisti, NML
Minchom, A
Barell, A
Cooley, B
Hanwell, J
Parlak, J
Banerji, U
De Bono, J
Sharp, A
Lopez, J
Battisti, NML
Minchom, A
Document Type
Journal Article
Date
2024-06-01
Date Accepted
2024-04-08
Abstract
BACKGROUND: Though cancer is more prevalent in the older population, this patient group are underrepresented in phase I oncology trials. AIMS: We evaluated the use of a geriatric screening tool (SAOP3) in patients of 70 years of age or older who attended a Phase I Clinical Trials Unit, with the aim of assessing the feasibility of the tool and identifying potential unmet needs in this patient group. METHODS: Twenty-two patients over the age of 70 completed the SAOP3 questionnaire. Geriatric impairments and needs were analysed with descriptive statistics. Qualitative responses were grouped in themes using structured thematic analysis. RESULTS: All of patients triggered at least 1 geriatric domain, most commonly mobility. Six core themes were identified as being important to the patient including family, friends and positivity. On cognition assessment over 20% of patients triggered as requiring further cognitive assessment. The group had a relatively high screen fail risk. CONCLUSION: In conclusion, routine geriatric screening withSAOP3 was feasible and identified areas of patient need. Results highlight the prevalence of psychological distress and cognitive impairment. Geriatric screening offers an opportunity for prehabilitation prior to trial and support during trial participation to optimise safety and improve trial access.
Citation
Cancer Reports, 2024, 7 (6), pp. e2083 -
Source Title
Cancer Reports
Publisher
WILEY
ISSN
2573-8348
eISSN
2573-8348
2573-8348
2573-8348
Collections
Research Team
Clinical Pharmacology
PrCa Targeted Therapy
Translational Therapeutic
Early Phase Drug Develop
Breast Cancer Clin Res
Adult DDU ICR & RM
PrCa Targeted Therapy
Translational Therapeutic
Early Phase Drug Develop
Breast Cancer Clin Res
Adult DDU ICR & RM