Advances in the treatment of advanced oestrogen-receptor-positive breast cancer.
Loading...
Embargo End Date
ICR Authors
Authors
Turner, NC
Neven, P
Loibl, S
Andre, F
Neven, P
Loibl, S
Andre, F
Document Type
Journal Article
Date
2017-06-17
Date Accepted
2016-08-24
Abstract
Oestrogen-receptor-positive breast cancer is the most common subtype of breast cancer. Endocrine therapies that target the dependence of this subtype on the oestrogen receptor have substantial activity, yet the development of resistance to therapy is inevitable in advanced cancer. Major progress has been made in identifying the drivers of oestrogen-receptor-positive breast cancer and the mechanisms of resistance to endocrine therapy. This progress has translated into major advances in the treatment of advanced breast cancer, with several targeted therapies that enhance the efficacy of endocrine therapy; inhibitors of mTOR and inhibitors of the cyclin-dependent kinases CDK4 and CDK6 substantially improve progression-free survival. A new wave of targeted therapies is being developed, including inhibitors of PI3K, AKT, and HER2, and a new generation of oestrogen-receptor degraders. Considerable challenges remain in patient selection, deciding on the most appropriate order in which to administer therapies, and establishing whether cross-resistance occurs between therapies.
Citation
Lancet (London, England), 2017, 389 (10087), pp. 2403 - 2414
Source Title
Publisher
ELSEVIER SCIENCE INC
ISSN
0140-6736
eISSN
1474-547X
Collections
Research Team
Molecular Oncology