Cancer cell - Fibroblast crosstalk via HB-EGF, EGFR, and MAPK signaling promotes the expression of macrophage chemo-attractants in squamous cell carcinoma.
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ICR Authors
Authors
Giangreco, G
Rullan, A
Naito, Y
Biswas, D
Liu, Y-H
Hooper, S
Nenclares, P
Bhide, S
Chon U Cheang, M
Chakravarty, P
Hirata, E
Swanton, C
Melcher, A
Harrington, K
Sahai, E
Rullan, A
Naito, Y
Biswas, D
Liu, Y-H
Hooper, S
Nenclares, P
Bhide, S
Chon U Cheang, M
Chakravarty, P
Hirata, E
Swanton, C
Melcher, A
Harrington, K
Sahai, E
Document Type
Journal Article
Date
2024-09-20
Date Accepted
2024-09-01
Date Available
2024-09-10T13:37:26Z
Abstract
Interactions between cells in the tumor microenvironment (TME) shape cancer progression and patient prognosis. To gain insights into how the TME influences cancer outcomes, we derive gene expression signatures indicative of signaling between stromal fibroblasts and cancer cells, and demonstrate their prognostic significance in multiple and independent squamous cell carcinoma cohorts. By leveraging information within the signatures, we discover that the HB-EGF/EGFR/MAPK axis represents a hub of tumor-stroma crosstalk, promoting the expression of CSF2 and LIF and favoring the recruitment of macrophages. Together, these analyses demonstrate the utility of our approach for interrogating the extent and consequences of TME crosstalk.
Citation
iScience, 2024, 27 (9), pp. 110635 - 110635
Source Title
iScience
Publisher
Elsevier BV
ISSN
2589-0042