An ionising radiation-induced specific transcriptional signature of inflammation-associated genes in whole blood from radiotherapy patients: a pilot study.
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ICR Authors
Authors
Cruz-Garcia, L
Badie, C
Anbalagan, S
Moquet, J
Gothard, L
O'Brien, G
Somaiah, N
Ainsbury, EA
Badie, C
Anbalagan, S
Moquet, J
Gothard, L
O'Brien, G
Somaiah, N
Ainsbury, EA
Document Type
Journal Article
Date
2021-05-03
Date Accepted
2021-04-13
Abstract
BACKGROUND: This communication reports the identification of a new panel of transcriptional changes in inflammation-associated genes observed in response to ionising radiation received by radiotherapy patients. METHODS: Peripheral blood samples were taken with ethical approval and informed consent from a total of 20 patients undergoing external beam radiotherapy for breast, lung, gastrointestinal or genitourinary tumours. Nanostring nCounter analysis of transcriptional changes was carried out in samples prior and 24 h post-delivery of the 1st radiotherapy fraction, just prior to the 5th or 6th fraction, and just before the last fraction. RESULTS: Statistical analysis with BRB-ArrayTools, GLM MANOVA and nSolver, revealed a radiation responsive panel of genes which varied by patient group (type of cancer) and with time since exposure (as an analogue for dose received), which may be useful as a biomarker of radiation response. CONCLUSION: Further validation in a wider group of patients is ongoing, together with work towards a full understanding of patient specific responses in support of personalised approaches to radiation medicine.
Citation
Radiation oncology (London, England), 2021, 16 (1), pp. 83 - ?
Source Title
Publisher
BMC
ISSN
1748-717X
eISSN
1748-717X
Collections
Research Team
Translational Breast Radiobiology
Translational Breast Radiobiology
Translational Breast Radiobiology