Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.
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ICR Authors
Authors
Thomas, DC
Clare, S
Sowerby, JM
Pardo, M
Juss, JK
Goulding, DA
van der Weyden, L
Storisteanu, D
Prakash, A
Espéli, M
Flint, S
Lee, JC
Hoenderdos, K
Kane, L
Harcourt, K
Mukhopadhyay, S
Umrania, Y
Antrobus, R
Nathan, JA
Adams, DJ
Bateman, A
Choudhary, JS
Lyons, PA
Condliffe, AM
Chilvers, ER
Dougan, G
Smith, KGC
Clare, S
Sowerby, JM
Pardo, M
Juss, JK
Goulding, DA
van der Weyden, L
Storisteanu, D
Prakash, A
Espéli, M
Flint, S
Lee, JC
Hoenderdos, K
Kane, L
Harcourt, K
Mukhopadhyay, S
Umrania, Y
Antrobus, R
Nathan, JA
Adams, DJ
Bateman, A
Choudhary, JS
Lyons, PA
Condliffe, AM
Chilvers, ER
Dougan, G
Smith, KGC
Document Type
Journal Article
Date
2017-04-03
Date Accepted
2017-01-20
Abstract
The phagocyte respiratory burst is crucial for innate immunity. The transfer of electrons to oxygen is mediated by a membrane-bound heterodimer, comprising gp91phox and p22phox subunits. Deficiency of either subunit leads to severe immunodeficiency. We describe Eros (essential for reactive oxygen species), a protein encoded by the previously undefined mouse gene bc017643, and show that it is essential for host defense via the phagocyte NAPDH oxidase. Eros is required for expression of the NADPH oxidase components, gp91phox and p22phox Consequently, Eros-deficient mice quickly succumb to infection. Eros also contributes to the formation of neutrophil extracellular traps (NETS) and impacts on the immune response to melanoma metastases. Eros is an ortholog of the plant protein Ycf4, which is necessary for expression of proteins of the photosynthetic photosystem 1 complex, itself also an NADPH oxio-reductase. We thus describe the key role of the previously uncharacterized protein Eros in host defense.
Citation
The Journal of experimental medicine, 2017, 214 (4), pp. 1111 - 1128
Source Title
Publisher
ROCKEFELLER UNIV PRESS
ISSN
0022-1007
eISSN
1540-9538
Collections
Research Team
Functional Proteomics Group