CNS cancer immunity cycle and strategies to target this for glioblastoma.
Embargo End Date
ICR Authors
Authors
Ameratunga, M
Coleman, N
Welsh, L
Saran, F
Lopez, J
Coleman, N
Welsh, L
Saran, F
Lopez, J
Document Type
Journal Article
Date
2018-04-27
Date Accepted
2018-03-11
Abstract
Immunotherapeutics have revolutionized the management of solid malignancies over the last few years. Nevertheless, despite relative successes of checkpoint inhibitors in numerous solid tumour types, success in tumours of the central nervous system (CNS) has been lacking. There are several possible reasons for the relative lack of success of immunotherapeutics in this setting, including the immune microenvironment of glioblastoma, lymphocyte tracking through the blood-brain barrier (BBB) into the central nervous system and impairment of drug delivery into the CNS through the BBB. This review utilizes the cancer-immunity cycle as a conceptual framework through which the specific challenges associated with the development of immunotherapeutics for CNS malignancies can be viewed.
Citation
Oncotarget, 2018, 9 (32), pp. 22802 - 22816
Source Title
Publisher
Impact Journals, LLC
ISSN
1949-2553
eISSN
1949-2553
Collections
Research Team
Medicine (de Bono Prostate)