Advances and challenges in targeting FGFR signalling in cancer.
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Embargo End Date
ICR Authors
Authors
Babina, IS
Turner, NC
Turner, NC
Document Type
Journal Article
Date
2016-11-18
Date Accepted
2016-11-18
Abstract
Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate numerous cellular processes. Deregulation of FGFR signalling is observed in a subset of many cancers, making activated FGFRs a highly promising potential therapeutic target supported by multiple preclinical studies. However, early-phase clinical trials have produced mixed results with FGFR-targeted cancer therapies, revealing substantial complexity to targeting aberrant FGFR signalling. In this Review, we discuss the increasing understanding of the differences between diverse mechanisms of oncogenic activation of FGFR, and the factors that determine response and resistance to FGFR targeting.
Citation
Nature reviews. Cancer, 2017, 17 (5), pp. 318 - 332
Source Title
Publisher
NATURE PORTFOLIO
ISSN
1474-175X
eISSN
1474-1768
Collections
Research Team
Molecular Oncology