Radiotherapy in Dupuytren's disease: a systematic review of the evidence.
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Embargo End Date
ICR Authors
Authors
Kadhum, M
Smock, E
Khan, A
Fleming, A
Smock, E
Khan, A
Fleming, A
Document Type
Journal Article
Date
2017-09-01
Date Accepted
2017-02-06
Abstract
UNLABELLED: Radiotherapy has been advocated as an alternative treatment in early Dupuytren's disease. We have systematically reviewed the evidence on the use of radiotherapy in Dupuytren's disease. Only six articles met a minimum set standard, five of which were retrospective cohort studies and one a randomized controlled study. A total of 770 Dupuytren's hands, nearly all with Tubiana stage 0-1 disease, were irradiated with an average 30 Gy. Disease regression ranged from 0%-56%, stability from 14%-98% and progression from 2%-86%. Salvage surgery was successful in all cases of disease progression post-radiotherapy. There were no reports of adverse wound healing problems associated with such surgery or radiotherapy-associated malignancy. On balance, radiotherapy should be considered an unproven treatment for early Dupuytren's disease due to a scarce evidence base and unknown long-term adverse effects. Well-designed randomized controlled studies are required to confirm the benefits of radiotherapy treatment. LEVEL OF EVIDENCE: II.
Citation
The Journal of hand surgery, European volume, 2017, 42 (7), pp. 689 - 692
Source Title
Publisher
SAGE PUBLICATIONS LTD
ISSN
1753-1934
eISSN
2043-6289
Research Team
Targeted Therapy