Predicting radiotherapy response, toxicities and quality of life related functional outcome in soft tissue sarcoma of the extremities (PredicT)
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Embargo End Date
2026-02-28
ICR Authors
Authors
Lopes Simoes Dos Reis Ferreira, R
Document Type
Thesis or Dissertation
Date
2025-08-28
Date Accepted
Abstract
Patients with soft tissue sarcoma of the extremities (STSE) can experience long-term permanent side-effects caused by radiotherapy, such as limb swelling, scar tissue formation, joint stiffness, all of which can lead to deterioration. Planning radiotherapy based on evidence-based dose-volume constraints and normal tissue sparing may lead to the development of less side-effects. However, these are unknown for STSE.
This thesis aims at predicting radiotherapy response, toxicities and quality-of-life (QoL) related functional outcomes in STSE (PredicT), as well as developing dose-volume constraints that when applied to normal tissues may result in less side-effects. PredicT consists of two cohorts:
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PredicT A (retrospective): predictive model will be developed using radiotherapy, toxicities, co-morbidities and patient reported outcome measures from 384 patients recruited in VorteX and IMRiS clinical trials. Dose-volume constraints will be derived using receiving operator characteristics and multivariate analysis.
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PredicT B (prospective validation): The validity of the dose-volume constraints will be tested using odds ratio in 80 patients of PredicT B observational study.
Citation
2025
DOI
Source Title
Publisher
Institute of Cancer Research (University Of London)
ISSN
eISSN
Collections
Research Team
Targeted Therapy