The UK HeartSpare Study (Stage II): Multicentre Evaluation of a Voluntary Breath-hold Technique in Patients Receiving Breast Radiotherapy.

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Embargo End Date

ICR Authors

McNair, Helen
 Griffin, Clare
 Haviland, Joanne
 Yarnold, John
 Kirby, Anna

Authors

Bartlett, FR
Donovan, EM
McNair, HA
Corsini, LA
Colgan, RM
Evans, PM
Maynard, L
Griffin, C
Haviland, JS
Yarnold, JR
Kirby, AM

Document Type

Journal Article

Date

2017-03-01

Date Accepted

2016-10-06

Abstract

AIMS: To evaluate the feasibility and heart-sparing ability of the voluntary breath-hold (VBH) technique in a multicentre setting. MATERIALS AND METHODS: Patients were recruited from 10 UK centres. Following surgery for early left breast cancer, patients with any heart inside the 50% isodose from a standard free-breathing tangential field treatment plan underwent a second planning computed tomography (CT) scan using the VBH technique. A separate treatment plan was prepared on the VBH CT scan and used for treatment. The mean heart, left anterior descending coronary artery (LAD) and lung doses were calculated. Daily electronic portal imaging (EPI) was carried out and scanning/treatment times were recorded. The primary end point was the percentage of patients achieving a reduction in mean heart dose with VBH. Population systematic (Σ) and random errors (σ) were estimated. Within-patient comparisons between techniques used Wilcoxon signed-rank tests. RESULTS: In total, 101 patients were recruited during 2014. Primary end point data were available for 93 patients, 88 (95%) of whom achieved a reduction in mean heart dose with VBH. Mean cardiac doses (Gy) for free-breathing and VBH techniques, respectively, were: heart 1.8 and 1.1, LAD 12.1 and 5.4, maximum LAD 35.4 and 24.1 (all P<0.001). Population EPI-based displacement data showed Σ =+1.3-1.9 mm and σ=1.4-1.8 mm. Median CT and treatment session times were 21 and 22 min, respectively. CONCLUSIONS: The VBH technique is confirmed as effective in sparing heart tissue and is feasible in a multicentre setting.

Citation

Clinical oncology (Royal College of Radiologists (Great Britain)), 2017, 29 (3), pp. e51 - e56

DOI

10.1016/j.clon.2016.11.005

URI

https://repository.icr.ac.uk/handle/internal/482

Rights

https://www.rioxx.net/licenses/all-rights-reserved

Source Title

Publisher

ELSEVIER SCIENCE LONDON

ISSN

0936-6555

eISSN

1433-2981

Collections

Radiotherapy and Imaging
Clinical Studies

Research Team

Clinical Trials & Statistics Unit
Breast Cancer Radiotherapy

Notes