CancerGD: A Resource for Identifying and Interpreting Genetic Dependencies in Cancer.
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Embargo End Date
ICR Authors
Authors
Bridgett, S
Campbell, J
Lord, CJ
Ryan, CJ
Campbell, J
Lord, CJ
Ryan, CJ
Document Type
Journal Article
Date
2017-07-26
Date Accepted
2017-06-08
Abstract
Genes whose function is selectively essential in the presence of cancer-associated genetic aberrations represent promising targets for the development of precision therapeutics. Here, we present CancerGD, a resource that integrates genotypic profiling with large-scale loss-of-function genetic screens in tumor cell lines to identify such genetic dependencies. CancerGD provides tools for searching, visualizing, and interpreting these genetic dependencies through the integration of functional interaction networks. CancerGD includes different screen types (siRNA, shRNA, CRISPR), and we describe a simple format for submitting new datasets.
Citation
Cell systems, 2017, 5 (1), pp. 82 - 86.e3
Source Title
Publisher
CELL PRESS
ISSN
2405-4712
eISSN
2405-4720
Collections
Research Team
Gene Function