The untapped potential of radiation and immunotherapy for hormone receptor-positive breast cancer.
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Authors
Fenton, M
Yoneyama, M
Wennerberg, E
Lund, T
Tutt, A
Melcher, A
Demaria, S
Somaiah, N
Yoneyama, M
Wennerberg, E
Lund, T
Tutt, A
Melcher, A
Demaria, S
Somaiah, N
Document Type
Journal Article
Date
2025-07-24
Date Accepted
2025-07-10
Abstract
Hormone receptor-positive breast cancers are a diverse group of tumours, with only some responding well to immunotherapy. Alternative combination strategies such as radiotherapy present an exciting opportunity to improve immunotherapy responses. We review an intriguing overlap between the impact of oestrogen signalling and radiation on multiple signalling pathways and immune cells that may be exploited for therapeutic gains in breast cancer. This is synthesised with the pre-clinical data and clinical trial landscape supporting the use of combined radiation and immunotherapy to derive insights for future neo-adjuvant trial design.
Citation
npj Breast Cancer, 2025, 11 (1), pp. 77 -
Source Title
npj Breast Cancer
Publisher
NATURE PORTFOLIO
ISSN
2374-4677
eISSN
2374-4677
Collections
Research Team
Trans Breast Radiobiol
Radiation Immunotherapy
Directorate Breast Canc
Radiation Immunotherapy
Directorate Breast Canc