A randomized control trial evaluating fluorescent ink versus dark ink tattoos for breast radiotherapy.
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ICR Authors
Authors
Landeg, SJ
Kirby, AM
Lee, SF
Bartlett, F
Titmarsh, K
Donovan, E
Griffin, CL
Gothard, L
Locke, I
McNair, HA
Kirby, AM
Lee, SF
Bartlett, F
Titmarsh, K
Donovan, E
Griffin, CL
Gothard, L
Locke, I
McNair, HA
Document Type
Journal Article
Date
2016-12-01
Date Accepted
2016-09-29
Abstract
OBJECTIVE: The purpose of this UK study was to evaluate interfraction reproducibility and body image score when using ultraviolet (UV) tattoos (not visible in ambient lighting) for external references during breast/chest wall radiotherapy and compare with conventional dark ink. METHODS: In this non-blinded, single-centre, parallel group, randomized control trial, patients were allocated to receive either conventional dark ink or UV ink tattoos using computer-generated random blocks. Participant assignment was not masked. Systematic (∑) and random (σ) setup errors were determined using electronic portal images. Body image questionnaires were completed at pre-treatment, 1 month and 6 months to determine the impact of tattoo type on body image. The primary end point was to determine that UV tattoo random error (σsetup) was no less accurate than with conventional dark ink tattoos, i.e. <2.8 mm. RESULTS: 46 patients were randomized to receive conventional dark or UV ink tattoos. 45 patients completed treatment (UV: n = 23, dark: n = 22). σsetup for the UV tattoo group was <2.8 mm in the u and v directions (p = 0.001 and p = 0.009, respectively). A larger proportion of patients reported improvement in body image score in the UV tattoo group compared with the dark ink group at 1 month [56% (13/23) vs 14% (3/22), respectively] and 6 months [52% (11/21) vs 38% (8/21), respectively]. CONCLUSION: UV tattoos were associated with interfraction setup reproducibility comparable with conventional dark ink. Patients reported a more favourable change in body image score up to 6 months following treatment. Advances in knowledge: This study is the first to evaluate UV tattoo external references in a randomized control trial.
Citation
The British journal of radiology, 2016, 89 (1068), pp. 20160288 - ?
Source Title
Publisher
OXFORD UNIV PRESS
ISSN
0007-1285
eISSN
1748-880X
Collections
Research Team
Clinical Trials & Statistics Unit
Breast Cancer Radiotherapy
Translational Breast Radiobiology
Breast Cancer Radiotherapy
Translational Breast Radiobiology