Functional immune responses against SARS-CoV-2 variants of concern after fourth COVID-19 vaccine dose or infection in patients with blood cancer.
Loading...
Embargo End Date
Authors
Fendler, A
Shepherd, STC
Au, L
Wu, M
Harvey, R
Wilkinson, KA
Schmitt, AM
Tippu, Z
Shum, B
Farag, S
Rogiers, A
Carlyle, E
Edmonds, K
Del Rosario, L
Lingard, K
Mangwende, M
Holt, L
Ahmod, H
Korteweg, J
Foley, T
Barber, T
Emslie-Henry, A
Caulfield-Lynch, N
Byrne, F
Deng, D
Kjaer, S
Song, O-R
Queval, CJ
Kavanagh, C
Wall, EC
Carr, EJ
Caidan, S
Gavrielides, M
MacRae, JI
Kelly, G
Peat, K
Kelly, D
Murra, A
Kelly, K
O'Flaherty, M
Shea, RL
Gardner, G
Murray, D
Popat, S
Yousaf, N
Jhanji, S
Tatham, K
Cunningham, D
Van As, N
Young, K
Furness, AJS
Pickering, L
Beale, R
Swanton, C
Gandhi, S
Gamblin, S
Bauer, DLV
Kassiotis, G
Howell, M
Nicholson, E
Walker, S
Wilkinson, RJ
Larkin, J
Turajlic, S
Shepherd, STC
Au, L
Wu, M
Harvey, R
Wilkinson, KA
Schmitt, AM
Tippu, Z
Shum, B
Farag, S
Rogiers, A
Carlyle, E
Edmonds, K
Del Rosario, L
Lingard, K
Mangwende, M
Holt, L
Ahmod, H
Korteweg, J
Foley, T
Barber, T
Emslie-Henry, A
Caulfield-Lynch, N
Byrne, F
Deng, D
Kjaer, S
Song, O-R
Queval, CJ
Kavanagh, C
Wall, EC
Carr, EJ
Caidan, S
Gavrielides, M
MacRae, JI
Kelly, G
Peat, K
Kelly, D
Murra, A
Kelly, K
O'Flaherty, M
Shea, RL
Gardner, G
Murray, D
Popat, S
Yousaf, N
Jhanji, S
Tatham, K
Cunningham, D
Van As, N
Young, K
Furness, AJS
Pickering, L
Beale, R
Swanton, C
Gandhi, S
Gamblin, S
Bauer, DLV
Kassiotis, G
Howell, M
Nicholson, E
Walker, S
Wilkinson, RJ
Larkin, J
Turajlic, S
Document Type
Journal Article
Date
2022-10-18
Date Accepted
2022-09-21
Abstract
Patients with blood cancer continue to have a greater risk of inadequate immune responses following three COVID-19 vaccine doses and risk of severe COVID-19 disease. In the context of the CAPTURE study (NCT03226886), we report immune responses in 80 patients with blood cancer who received a fourth dose of BNT162b2. We measured neutralizing antibody titers (NAbTs) using a live virus microneutralization assay against wild-type (WT), Delta, and Omicron BA.1 and BA.2 and T cell responses against WT and Omicron BA.1 using an activation-induced marker (AIM) assay. The proportion of patients with detectable NAb titers and T cell responses after the fourth vaccine dose increased compared with that after the third vaccine dose. Patients who received B cell-depleting therapies within the 12 months before vaccination have the greatest risk of not having detectable NAbT. In addition, we report immune responses in 57 patients with breakthrough infections after vaccination.
Citation
Cell Reports Medicine, 2022, 3 (10), pp. 100781 -
Source Title
Cell Reports Medicine
Publisher
CELL PRESS
ISSN
2666-3791
eISSN
2666-3791
2666-3791
2666-3791
Collections
Research Team
Melanoma & Kidney Cancer
Medicine (RMH)
Skin Unit
Medicine (RMH)
Skin Unit