Targeting deficient DNA damage repair in gastric cancer.
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Embargo End Date
ICR Authors
Authors
Young, K
Starling, N
Cunningham, D
Starling, N
Cunningham, D
Document Type
Journal Article
Date
2016-09-01
Date Accepted
Abstract
INTRODUCTION: Over recent years our understanding of DNA damage repair has evolved leading to an expansion of therapies attempting to exploit DNA damage repair deficiencies across multiple solid tumours. Gastric cancer has been identified as a tumour where a subgroup of patients demonstrates deficiencies in the homologous recombination pathway providing a potential novel treatment approach for this poor prognosis disease. AREA COVERED: This review provides an overview of DNA damage repair and how this has been targeted to date in other tumour types exploiting the concept of synthetic lethality. This is followed by a discussion of how deficiencies in homologous recombination may be identified across tumour types and on recent progress in targeting DNA repair deficiencies in gastric cancer. EXPERT OPINION: Gastric cancer remains a difficult malignancy to treat and the possibility of targeting deficient DNA repair in a subgroup of patients is an exciting prospect. Future combinations with immunotherapy and radiotherapy are appealing and appear to have a sound biological rationale. However, much work remains to be done to understand the significance of the genetic and epigenetic alterations involved, to elucidate the optimum predictive signatures or biomarkers and to consider means of overcoming treatment resistance.
Citation
Expert opinion on pharmacotherapy, 2016, 17 (13), pp. 1757 - 1766
Source Title
Publisher
TAYLOR & FRANCIS LTD
ISSN
1465-6566
eISSN
1744-7666
Collections
Research Team
Gastrointestinal Cancers Clinical Trials
Medicine (RMH Smith Cunningham)
Medicine (RMH Smith Cunningham)