Pembrolizumab given concomitantly with chemoradiation and as maintenance therapy for locally advanced head and neck squamous cell carcinoma: KEYNOTE-412.
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Embargo End Date
ICR Authors
Authors
Machiels, J-P
Tao, Y
Burtness, B
Tahara, M
Licitra, L
Rischin, D
Waldron, J
Simon, C
Gregoire, V
Harrington, K
Alves, GV
Figueiredo Lima, IP
Pointreau, Y
M Hughes, BG
Aksoy, S
Hetnal, M
Ge, JY
Brown, H
Cheng, J
Bidadi, B
Siu, LL
Tao, Y
Burtness, B
Tahara, M
Licitra, L
Rischin, D
Waldron, J
Simon, C
Gregoire, V
Harrington, K
Alves, GV
Figueiredo Lima, IP
Pointreau, Y
M Hughes, BG
Aksoy, S
Hetnal, M
Ge, JY
Brown, H
Cheng, J
Bidadi, B
Siu, LL
Document Type
Journal Article
Date
2020-06-03
Date Accepted
2020-04-17
Abstract
Current treatment guidelines for patients with locally advanced head and neck squamous cell carcinoma (HNSCC) recommend multimodal treatment, including chemoradiation therapy (CRT) or surgery followed by radiation, with or without chemotherapy. The immune checkpoint inhibitor pembrolizumab has previously demonstrated antitumor activity in recurrent and/or metastatic HNSCC in large Phase III trials. For patients with locally advanced disease, Phase Ib data on the use of pembrolizumab in combination with chemoradiation have shown the approach to be safe and feasible. We describe here the design and rationale for KEYNOTE-412, a randomized, double-blind, Phase III trial investigating pembrolizumab or placebo administered concurrently with CRT and as maintenance treatment in patients with locally advanced HNSCC. Clinical Trial Registration: NCT03040999 (ClinicalTrials.gov).
Citation
Future oncology (London, England), 2020, 16 (18), pp. 1235 - 1243
Source Title
Publisher
TAYLOR & FRANCIS LTD
ISSN
1479-6694
eISSN
1744-8301
Collections
Research Team
Targeted Therapy
Targeted Therapy
Targeted Therapy