Pembrolizumab given concomitantly with chemoradiation and as maintenance therapy for locally advanced head and neck squamous cell carcinoma: KEYNOTE-412.

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Authors

Machiels, J-P
Tao, Y
Burtness, B
Tahara, M
Licitra, L
Rischin, D
Waldron, J
Simon, C
Gregoire, V
Harrington, K
Alves, GV
Figueiredo Lima, IP
Pointreau, Y
M Hughes, BG
Aksoy, S
Hetnal, M
Ge, JY
Brown, H
Cheng, J
Bidadi, B
Siu, LL

Document Type

Journal Article

Date

2020-06-03

Date Accepted

2020-04-17

Abstract

Current treatment guidelines for patients with locally advanced head and neck squamous cell carcinoma (HNSCC) recommend multimodal treatment, including chemoradiation therapy (CRT) or surgery followed by radiation, with or without chemotherapy. The immune checkpoint inhibitor pembrolizumab has previously demonstrated antitumor activity in recurrent and/or metastatic HNSCC in large Phase III trials. For patients with locally advanced disease, Phase Ib data on the use of pembrolizumab in combination with chemoradiation have shown the approach to be safe and feasible. We describe here the design and rationale for KEYNOTE-412, a randomized, double-blind, Phase III trial investigating pembrolizumab or placebo administered concurrently with CRT and as maintenance treatment in patients with locally advanced HNSCC. Clinical Trial Registration: NCT03040999 (ClinicalTrials.gov).

Citation

Future oncology (London, England), 2020, 16 (18), pp. 1235 - 1243

Source Title

Publisher

TAYLOR & FRANCIS LTD

ISSN

1479-6694

eISSN

1744-8301

Research Team

Targeted Therapy
Targeted Therapy

Notes