Influence of obesity-related risk factors in the aetiology of glioma.
Loading...
Embargo End Date
Authors
Disney-Hogg, L
Sud, A
Law, PJ
Cornish, AJ
Kinnersley, B
Ostrom, QT
Labreche, K
Eckel-Passow, JE
Armstrong, GN
Claus, EB
Il'yasova, D
Schildkraut, J
Barnholtz-Sloan, JS
Olson, SH
Bernstein, JL
Lai, RK
Swerdlow, AJ
Simon, M
Hoffmann, P
Nöthen, MM
Jöckel, K-H
Chanock, S
Rajaraman, P
Johansen, C
Jenkins, RB
Melin, BS
Wrensch, MR
Sanson, M
Bondy, ML
Houlston, RS
Sud, A
Law, PJ
Cornish, AJ
Kinnersley, B
Ostrom, QT
Labreche, K
Eckel-Passow, JE
Armstrong, GN
Claus, EB
Il'yasova, D
Schildkraut, J
Barnholtz-Sloan, JS
Olson, SH
Bernstein, JL
Lai, RK
Swerdlow, AJ
Simon, M
Hoffmann, P
Nöthen, MM
Jöckel, K-H
Chanock, S
Rajaraman, P
Johansen, C
Jenkins, RB
Melin, BS
Wrensch, MR
Sanson, M
Bondy, ML
Houlston, RS
Document Type
Journal Article
Date
2018-04-01
Date Accepted
2018-01-08
Abstract
BACKGROUND: Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation framework to examine whether obesity-related traits influence glioma risk. This methodology reduces bias from confounding and is not affected by reverse causation. METHODS: Genetic instruments were identified for 10 key obesity-related risk factors, and their association with glioma risk was evaluated using data from a genome-wide association study of 12,488 glioma patients and 18,169 controls. The estimated odds ratio of glioma associated with each of the genetically defined obesity-related traits was used to infer evidence for a causal relationship. RESULTS: No convincing association with glioma risk was seen for genetic instruments for body mass index, waist-to-hip ratio, lipids, type-2 diabetes, hyperglycaemia or insulin resistance. Similarly, we found no evidence to support a relationship between obesity-related traits with subtypes of glioma-glioblastoma (GBM) or non-GBM tumours. CONCLUSIONS: This study provides no evidence to implicate obesity-related factors as causes of glioma.
Citation
British journal of cancer, 2018, 118 (7), pp. 1020 - 1027
Source Title
Publisher
SPRINGERNATURE
ISSN
0007-0920
eISSN
1532-1827
Research Team
Aetiological Epidemiology
Cancer Genomics
Cancer Genomics