The Eukaryotic Linear Motif resource: 2022 release.
Loading...
ICR Authors
Authors
Kumar, M
Michael, S
Alvarado-Valverde, J
Mészáros, B
Sámano-Sánchez, H
Zeke, A
Dobson, L
Lazar, T
Örd, M
Nagpal, A
Farahi, N
Käser, M
Kraleti, R
Davey, NE
Pancsa, R
Chemes, LB
Gibson, TJ
Michael, S
Alvarado-Valverde, J
Mészáros, B
Sámano-Sánchez, H
Zeke, A
Dobson, L
Lazar, T
Örd, M
Nagpal, A
Farahi, N
Käser, M
Kraleti, R
Davey, NE
Pancsa, R
Chemes, LB
Gibson, TJ
Document Type
Journal Article
Date
2022-01-07
Date Accepted
2021-10-27
Date Available
2022-01-26T16:00:23Z
Abstract
Almost twenty years after its initial release, the Eukaryotic Linear Motif (ELM) resource remains an invaluable source of information for the study of motif-mediated protein-protein interactions. ELM provides a comprehensive, regularly updated and well-organised repository of manually curated, experimentally validated short linear motifs (SLiMs). An increasing number of SLiM-mediated interactions are discovered each year and keeping the resource up-to-date continues to be a great challenge. In the current update, 30 novel motif classes have been added and five existing classes have undergone major revisions. The update includes 411 new motif instances mostly focused on cell-cycle regulation, control of the actin cytoskeleton, membrane remodelling and vesicle trafficking pathways, liquid-liquid phase separation and integrin signalling. Many of the newly annotated motif-mediated interactions are targets of pathogenic motif mimicry by viral, bacterial or eukaryotic pathogens, providing invaluable insights into the molecular mechanisms underlying infectious diseases. The current ELM release includes 317 motif classes incorporating 3934 individual motif instances manually curated from 3867 scientific publications. ELM is available at: http://elm.eu.org.
Citation
Nucleic acids research, 2022, 50 (D1), pp. D497 - D508
Source Title
Publisher
OXFORD UNIV PRESS
ISSN
0305-1048
eISSN
1362-4962
1362-4962
1362-4962