Functional antibody and T cell immunity following SARS-CoV-2 infection, including by variants of concern, in patients with cancer: the CAPTURE study.
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Authors
Fendler, A
Au, L
Shepherd, STC
Byrne, F
Cerrone, M
Boos, LA
Rzeniewicz, K
Gordon, W
Shum, B
Gerard, CL
Ward, B
Xie, W
Schmitt, AM
Joharatnam-Hogan, N
Cornish, GH
Pule, M
Mekkaoui, L
Ng, KW
Carlyle, E
Edmonds, K
Rosario, LD
Sarker, S
Lingard, K
Mangwende, M
Holt, L
Ahmod, H
Stone, R
Gomes, C
Flynn, HR
Agua-Doce, A
Hobson, P
Caidan, S
Howell, M
Wu, M
Goldstone, R
Crawford, M
Cubitt, L
Patel, H
Gavrielides, M
Nye, E
Snijders, AP
MacRae, JI
Nicod, J
Gronthoud, F
Shea, RL
Messiou, C
Cunningham, D
Chau, I
Starling, N
Turner, N
Welsh, L
van As, N
Jones, RL
Droney, J
Banerjee, S
Tatham, KC
Jhanji, S
O'Brien, M
Curtis, O
Harrington, K
Bhide, S
Bazin, J
Robinson, A
Stephenson, C
Slattery, T
Khan, Y
Tippu, Z
Leslie, I
Gennatas, S
Okines, A
Reid, A
Young, K
Furness, AJS
Pickering, L
Gandhi, S
Gamblin, S
Swanton, C
Crick COVID-19 Consortium,
Nicholson, E
Kumar, S
Yousaf, N
Wilkinson, KA
Swerdlow, A
Harvey, R
Kassiotis, G
Larkin, J
Wilkinson, RJ
Turajlic, S
CAPTURE consortium,
Au, L
Shepherd, STC
Byrne, F
Cerrone, M
Boos, LA
Rzeniewicz, K
Gordon, W
Shum, B
Gerard, CL
Ward, B
Xie, W
Schmitt, AM
Joharatnam-Hogan, N
Cornish, GH
Pule, M
Mekkaoui, L
Ng, KW
Carlyle, E
Edmonds, K
Rosario, LD
Sarker, S
Lingard, K
Mangwende, M
Holt, L
Ahmod, H
Stone, R
Gomes, C
Flynn, HR
Agua-Doce, A
Hobson, P
Caidan, S
Howell, M
Wu, M
Goldstone, R
Crawford, M
Cubitt, L
Patel, H
Gavrielides, M
Nye, E
Snijders, AP
MacRae, JI
Nicod, J
Gronthoud, F
Shea, RL
Messiou, C
Cunningham, D
Chau, I
Starling, N
Turner, N
Welsh, L
van As, N
Jones, RL
Droney, J
Banerjee, S
Tatham, KC
Jhanji, S
O'Brien, M
Curtis, O
Harrington, K
Bhide, S
Bazin, J
Robinson, A
Stephenson, C
Slattery, T
Khan, Y
Tippu, Z
Leslie, I
Gennatas, S
Okines, A
Reid, A
Young, K
Furness, AJS
Pickering, L
Gandhi, S
Gamblin, S
Swanton, C
Crick COVID-19 Consortium,
Nicholson, E
Kumar, S
Yousaf, N
Wilkinson, KA
Swerdlow, A
Harvey, R
Kassiotis, G
Larkin, J
Wilkinson, RJ
Turajlic, S
CAPTURE consortium,
Document Type
Journal Article
Date
2021-09-20
Date Accepted
2021-09-17
Abstract
Patients with cancer have higher COVID-19 morbidity and mortality. Here we present the prospective CAPTURE study, integrating longitudinal immune profiling with clinical annotation. Of 357 patients with cancer, 118 were SARS-CoV-2 positive, 94 were symptomatic and 2 died of COVID-19. In this cohort, 83% patients had S1-reactive antibodies and 82% had neutralizing antibodies against wild type SARS-CoV-2, whereas neutralizing antibody titers against the Alpha, Beta and Delta variants were substantially reduced. S1-reactive antibody levels decreased in 13% of patients, whereas neutralizing antibody titers remained stable for up to 329 days. Patients also had detectable SARS-CoV-2-specific T cells and CD4+ responses correlating with S1-reactive antibody levels, although patients with hematological malignancies had impaired immune responses that were disease and treatment specific, but presented compensatory cellular responses, further supported by clinical recovery in all but one patient. Overall, these findings advance the understanding of the nature and duration of the immune response to SARS-CoV-2 in patients with cancer.
Citation
Nature Cancer, 2021, 2 (12), pp. 1321 - 1337
Source Title
Publisher
NATURE PORTFOLIO
ISSN
eISSN
2662-1347
2662-1347
2662-1347
Research Team
Medicine (RMH Smith Cunningham)
Melanoma and Kidney Cancer
Targeted Therapy
Melanoma and Kidney Cancer
Targeted Therapy