Emerging biomarkers for PD-1 pathway cancer therapy.
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Embargo End Date
ICR Authors
Authors
Lim, JS
Sundar, R
Chénard-Poirier, M
Lopez, J
Yap, TA
Sundar, R
Chénard-Poirier, M
Lopez, J
Yap, TA
Document Type
Journal Article
Date
2017-01-01
Date Accepted
Abstract
The field of immuno-oncology has witnessed unprecedented success in recent years, with several PD=1 and PD-L1 inhibitors obtaining US FDA registration and breakthrough drug therapy designation in multiple tumor types. Despite its clear efficacy in certain cancers, treatment with these agents carries a risk of immune-related toxicities and substantial financial burden. It is, therefore, critical to identify patients likely to benefit from such immunotherapies and develop strategies to differentiate responders from nonresponders early during treatment. Here we discuss the development of predictive and treatment response biomarkers for immune checkpoint inhibitors. We first examine the role of PD-L1 expression, the most extensively studied predictive biomarker of response, and further discuss emerging putative predictive biomarkers. We also detail challenges faced in the development of response assessments for immunotherapeutics and propose other biomarkers that may be useful as surrogate intermediate end points of response.
Citation
Biomarkers in medicine, 2017, 11 (1), pp. 53 - 67
Source Title
Publisher
FUTURE MEDICINE LTD
ISSN
1752-0363
eISSN
1752-0371
Collections
Research Team
Medicine (de Bono Prostate)
Medicine Drug Development Unit (de Bono)
Medicine Drug Development Unit (de Bono)