Impact of chemotherapy on the outcome of osteosarcoma of the head and neck in adults.

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ICR Authors

van der Graaf, Wilhelmina
 Marsden,

Authors

Boon, E
van der Graaf, WTA
Gelderblom, H
Tesselaar, MET
van Es, RJJ
Oosting, SF
de Bree, R
van Meerten, E
Hoeben, A
Smeele, LE
Willems, SM
Witjes, MJH
Buter, J
Baatenburg de Jong, RJ
Flucke, UE
Peer, PGM
Bovée, JVMG
Van Herpen, CML

Document Type

Journal Article

Date

2017-01

Date Accepted

2016-06-24

Abstract

Background There is an ongoing debate about the value of (neo-)adjuvant chemotherapy in high- and intermediate-grade osteosarcoma of the head and neck.Methods All records of patients older than 16 years diagnosed with osteosarcoma of the head and neck in the Netherlands between 1993 and 2013 were reviewed.Results We identified a total of 77 patients with an osteosarcoma of the head and neck; the 5-year overall survival (OS) was 55%. In 50 patients with surgically resected high- or intermediate-grade osteosarcoma of the head and neck younger than 75 years, univariate and multivariable analysis, adjusting for age and resection margins, showed that patients who had not received chemotherapy had a significantly higher risk of local recurrence (hazard ratio [HR] = 3.78 and 3.66, respectively).Conclusion In patients younger than 75 years of age with surgically resected high- and intermediate-grade osteosarcoma of the head and neck, treatment with (neo-)adjuvant chemotherapy resulted in a significantly smaller risk of local recurrence. Therefore, we suggest (neo-)adjuvant chemotherapy in patients amenable to chemotherapy. © 2016 The Authors Head & Neck Published by Wiley Periodicals, Inc. Head Neck 39: 140-146, 2017.

Citation

Head & neck, 2017, 39 (1), pp. 140 - 146

DOI

10.1002/hed.24556

URI

https://repository.icr.ac.uk/handle/internal/45

Rights

https://creativecommons.org/licenses/by-nc-nd/4.0

Source Title

Publisher

ISSN

1043-3074

eISSN

1097-0347

Collections

Clinical Studies

Research Team

Clinical and Translational Sarcoma

Notes