Acute skin toxicity associated with a 1-week schedule of whole breast radiotherapy compared with a standard 3-week regimen delivered in the UK FAST-Forward Trial.

Thumbnail Image

Files

FF 1-s2.0-S0167814016001158-main.pdf (444.17 KB)

Embargo End Date

ICR Authors

Yarnold, John
 Somaiah, Navita
 Sydenham, Mark
 Griffin, Clare
 Bliss, Judith

Authors

Brunt, AM
Wheatley, D
Yarnold, J
Somaiah, N
Kelly, S
Harnett, A
Coles, C
Goodman, A
Bahl, A
Churn, M
Zotova, R
Sydenham, M
Griffin, CL
Morden, JP
Bliss, JM
FAST-Forward Trial Management Group,

Document Type

Journal Article

Date

2016-07-15

Date Accepted

2016-02-22

Abstract

BACKGROUND AND PURPOSE: FAST-Forward is a phase 3 clinical trial testing a 1-week course of whole breast radiotherapy against the UK standard 3-week regimen after primary surgery for early breast cancer. Two acute skin toxicity substudies were undertaken to test the safety of the test schedules with respect to early skin reactions. MATERIAL AND METHODS: Patients were randomly allocated to 40Gy/15 fractions (F)/3-weeks, 27Gy/5F/1-week or 26Gy/5F/1-week. Acute breast skin reactions were graded using RTOG (first substudy) and CTCAE criteria v4.03 (second substudy) weekly during treatment and for 4weeks after treatment ended. Primary endpoint was the proportion of patients within each treatment group with grade ⩾3 toxicity (RTOG and CTCAE, respectively) at any time from the start of radiotherapy to 4weeks after completion. RESULTS: 190 and 162 patients were recruited. In the first substudy, evaluable patients with grade 3 RTOG toxicity were: 40Gy/15F 6/44 (13.6%); 27Gy/5F 5/51 (9.8%); 26Gy/5F 3/52 (5.8%). In the second substudy, evaluable patients with grade 3 CTCAE toxicity were: 40Gy/15F 0/43; 27Gy/5F 1/41 (2.4%); 26Gy/5F 0/53. CONCLUSIONS: Acute breast skin reactions with two 1-week schedules of whole breast radiotherapy under test in FAST-Forward were mild.

Citation

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2016, 120 (1), pp. 114 - 118

DOI

10.1016/j.radonc.2016.02.027

URI

https://repository.icr.ac.uk/handle/internal/81

Rights

https://creativecommons.org/licenses/by/4.0

Source Title

Publisher

ELSEVIER IRELAND LTD

ISSN

0167-8140

eISSN

1879-0887

Collections

Clinical Studies
Radiotherapy and Imaging

Research Team

Clinical Trials & Statistics Unit
Translational Breast Radiobiology

Notes