Pazopanib in patients with advanced intermediate-grade or high-grade liposarcoma.
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Embargo End Date
ICR Authors
Authors
Chamberlain, FE
Wilding, C
Jones, RL
Huang, P
Wilding, C
Jones, RL
Huang, P
Document Type
Journal Article
Date
2019-07-03
Date Accepted
Abstract
Introduction: Liposarcomas (LPS) are a heterogeneous group of adipocytic soft tissue sarcomas with limited treatment options in the advanced/metastatic setting. Pazopanib is a multi-target tyrosine kinase inhibitor (TKI) with anti-angiogenic and antitumorigenic properties. Whilst targeted agents including TKIs have been extensively studied in other solid tumors and the sarcoma subtype gastrointestinal stromal tumor (GIST), we currently lack effective treatments for the liposarcoma subtype. Several phase II and III studies of oral TKIs in soft tissue sarcomas have excluded liposarcoma because of a reported lack of activity following the EORTC 62043 study. Areas: We review the use of pazopanib in advanced intermediate and high-grade liposarcomas where complete surgical resection is not possible. Expert opinion: The current clinical and pharmacological data demonstrate the efficacy of pazopanib in soft tissue sarcomas, but new data suggest that anti-angiogenic agents may have limited activity in liposarcoma. Anti-angiogenic TKIs are generally well tolerated and liposarcomas vary in their response to systemic chemotherapy; hence, there is a role for further exploration of the efficacy of this treatment amongst the histological subtypes of liposarcoma. This affords further understanding of biomarkers which may be associated with response to pazopanib and other anti-angiogenic TKI treatments.
Citation
Expert opinion on investigational drugs, 2019, 28 (6), pp. 505 - 511
Source Title
Publisher
TAYLOR & FRANCIS LTD
ISSN
1354-3784
eISSN
1744-7658
Collections
Research Team
Sarcoma Clinical Trials (R Jones)
Molecular and Systems Oncology
Molecular and Systems Oncology