Challenges to curing primary brain tumours.
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ICR Authors
Authors
Aldape, K
Brindle, KM
Chesler, L
Chopra, R
Gajjar, A
Gilbert, MR
Gottardo, N
Gutmann, DH
Hargrave, D
Holland, EC
Jones, DTW
Joyce, JA
Kearns, P
Kieran, MW
Mellinghoff, IK
Merchant, M
Pfister, SM
Pollard, SM
Ramaswamy, V
Rich, JN
Robinson, GW
Rowitch, DH
Sampson, JH
Taylor, MD
Workman, P
Gilbertson, RJ
Brindle, KM
Chesler, L
Chopra, R
Gajjar, A
Gilbert, MR
Gottardo, N
Gutmann, DH
Hargrave, D
Holland, EC
Jones, DTW
Joyce, JA
Kearns, P
Kieran, MW
Mellinghoff, IK
Merchant, M
Pfister, SM
Pollard, SM
Ramaswamy, V
Rich, JN
Robinson, GW
Rowitch, DH
Sampson, JH
Taylor, MD
Workman, P
Gilbertson, RJ
Document Type
Journal Article
Date
2019-08-01
Date Accepted
Abstract
Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.
Citation
Nature reviews. Clinical oncology, 2019, 16 (8), pp. 509 - 520
Source Title
Publisher
NATURE PUBLISHING GROUP
ISSN
1759-4774
eISSN
1759-4782
Research Team
Paediatric Solid Tumour Biology and Therapeutics