Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network.
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ICR Authors
Authors
Demetri, GD
Antonescu, CR
Bjerkehagen, B
Bovée, JVMG
Boye, K
Chacón, M
Dei Tos, AP
Desai, J
Fletcher, JA
Gelderblom, H
George, S
Gronchi, A
Haas, RL
Hindi, N
Hohenberger, P
Joensuu, H
Jones, RL
Judson, I
Kang, Y-K
Kawai, A
Lazar, AJ
Le Cesne, A
Maestro, R
Maki, RG
Martín, J
Patel, S
Penault-Llorca, F
Premanand Raut, C
Rutkowski, P
Safwat, A
Sbaraglia, M
Schaefer, I-M
Shen, L
Serrano, C
Schöffski, P
Stacchiotti, S
Sundby Hall, K
Tap, WD
Thomas, DM
Trent, J
Valverde, C
van der Graaf, WTA
von Mehren, M
Wagner, A
Wardelmann, E
Naito, Y
Zalcberg, J
Blay, J-Y
Antonescu, CR
Bjerkehagen, B
Bovée, JVMG
Boye, K
Chacón, M
Dei Tos, AP
Desai, J
Fletcher, JA
Gelderblom, H
George, S
Gronchi, A
Haas, RL
Hindi, N
Hohenberger, P
Joensuu, H
Jones, RL
Judson, I
Kang, Y-K
Kawai, A
Lazar, AJ
Le Cesne, A
Maestro, R
Maki, RG
Martín, J
Patel, S
Penault-Llorca, F
Premanand Raut, C
Rutkowski, P
Safwat, A
Sbaraglia, M
Schaefer, I-M
Shen, L
Serrano, C
Schöffski, P
Stacchiotti, S
Sundby Hall, K
Tap, WD
Thomas, DM
Trent, J
Valverde, C
van der Graaf, WTA
von Mehren, M
Wagner, A
Wardelmann, E
Naito, Y
Zalcberg, J
Blay, J-Y
Document Type
Journal Article
Date
2020-11-01
Date Accepted
2020-08-21
Abstract
Sarcomas are a heterogeneous group of malignancies with mesenchymal lineage differentiation. The discovery of neurotrophic tyrosine receptor kinase (NTRK) gene fusions as tissue-agnostic oncogenic drivers has led to new personalized therapies for a subset of patients with sarcoma in the form of tropomyosin receptor kinase (TRK) inhibitors. NTRK gene rearrangements and fusion transcripts can be detected with different molecular pathology techniques, while TRK protein expression can be demonstrated with immunohistochemistry. The rarity and diagnostic complexity of NTRK gene fusions raise a number of questions and challenges for clinicians. To address these challenges, the World Sarcoma Network convened two meetings of expert adult oncologists and pathologists and subsequently developed this article to provide practical guidance on the management of patients with sarcoma harboring NTRK gene fusions. We propose a diagnostic strategy that considers disease stage and histologic and molecular subtypes to facilitate routine testing for TRK expression and subsequent testing for NTRK gene fusions.
Citation
Annals of oncology : official journal of the European Society for Medical Oncology, 2020, 31 (11), pp. 1506 - 1517
Source Title
Publisher
ELSEVIER
ISSN
0923-7534
eISSN
1569-8041
Collections
Research Team
Sarcoma Clinical Trials