Near-InfraRed PhotoImmunoTherapy (NIR-PIT) for the local control of solid cancers: Challenges and potentials for human applications.
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Embargo End Date
ICR Authors
Authors
Paraboschi, I
Turnock, S
Kramer-Marek, G
Musleh, L
Barisa, M
Anderson, J
Giuliani, S
Turnock, S
Kramer-Marek, G
Musleh, L
Barisa, M
Anderson, J
Giuliani, S
Document Type
Journal Article
Date
2021-05-01
Date Accepted
2021-03-26
Abstract
Near-InfraRed PhotoImmunoTherapy (NIR-PIT) is a novel cancer-targeted treatment effected by a chemical conjugation between a photosensitiser (e.g. the NIR phthalocyanine dye IRDye700DX) and a cancer-targeting moiety (e.g. a monoclonal antibody, moAb). Delivery of a conjugate in vivo leads to accumulation at the tumour cell surface by binding to cell surface receptors or antigens. Upon deployment of focal NIR-light, irradiation of the conjugate results in a rapid, targeted cell death. However, the mechanisms of action to produce the cytotoxic effects have yet to be fully understood. Herein, we bring together the current knowledge of NIR-PIT from preclinical and clinical studies in a variety of cancers highlighting the key unanswered research questions. Furthermore, we discuss how to enhance the local control of solid cancers using this novel treatment regimen.
Citation
Critical reviews in oncology/hematology, 2021, 161 pp. 103325 - ?
Source Title
Publisher
ELSEVIER SCIENCE INC
ISSN
1040-8428
eISSN
1879-0461
Collections
Research Team
Preclinical Molecular Imaging
Preclinical Molecular Imaging
Preclinical Molecular Imaging