Characterising spatial heterogeneity of multiple myeloma in high resolution by whole body magnetic resonance imaging: Towards macro-phenotype driven patient management.
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Embargo End Date
ICR Authors
Authors
Latifoltojar, A
Boyd, K
Riddell, A
Kaiser, M
Messiou, C
Boyd, K
Riddell, A
Kaiser, M
Messiou, C
Document Type
Journal Article
Date
2021-01-01
Date Accepted
2020-10-14
Abstract
Diagnosis of patients suspected of multiple myeloma requires a combination of serological and biochemical tests, bone marrow aspirate (BMA) and/or bone marrow trephine (BMT) biopsies as well as complementary information provided by whole-body cross-sectional imaging studies. However, given the heterogeneous nature of multiple myeloma, discrepancies can arise between disease burden on trephine and extent of disease within the marrow on whole-body magnetic resonance imaging (WB-MRI). Here, for the first time, we report on a series of symptomatic multiple myeloma patients for whom there was substantial discordance between disease burden on trephine and WB-MRI.
Citation
Magnetic resonance imaging, 2021, 75 pp. 60 - 64
Source Title
Publisher
ELSEVIER SCIENCE INC
ISSN
0730-725X
eISSN
1873-5894
Collections
Research Team
Myeloma Group