Exploring the genetic space of the DNA damage response for cancer therapy through CRISPR-based screens.
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Embargo End Date
ICR Authors
Authors
Wilson, J
Loizou, JI
Loizou, JI
Document Type
Journal Article
Date
2022-11-01
Date Accepted
2022-06-14
Abstract
The concepts of synthetic lethality and viability have emerged as powerful approaches to identify vulnerabilities and resistances within the DNA damage response for the treatment of cancer. Historically, interactions between two genes have had a longstanding presence in genetics and have been identified through forward genetic screens that rely on the molecular basis of the characterized phenotypes, typically caused by mutations in single genes. While such complex genetic interactions between genes have been studied extensively in model organisms, they have only recently been prioritized as therapeutic strategies due to technological advancements in genetic screens. Here, we discuss synthetic lethal and viable interactions within the DNA damage response and present how CRISPR-based genetic screens and chemical compounds have allowed for the systematic identification and targeting of such interactions for the treatment of cancer.
Citation
Molecular Oncology, 2022, 16 (21), pp. 3778 - 3791
Source Title
Molecular Oncology
Publisher
WILEY
ISSN
1574-7891
eISSN
1878-0261
Collections
Research Team
Target Val & Genome Stab