Active multiple myeloma suppresses and typically eliminates coexisting MGUS.
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Embargo End Date
ICR Authors
Authors
Campbell, JP
Heaney, JLJ
Pandya, S
Afzal, Z
Kaiser, M
Owen, R
Child, JA
Gregory, W
Morgan, GJ
Jackson, GH
Bunce, CM
Drayson, MT
Heaney, JLJ
Pandya, S
Afzal, Z
Kaiser, M
Owen, R
Child, JA
Gregory, W
Morgan, GJ
Jackson, GH
Bunce, CM
Drayson, MT
Document Type
Journal Article
Date
2017-09-05
Date Accepted
2017-06-22
Abstract
BACKGROUND: Myeloma is consistently preceded by premalignant monoclonal gammopathy of undetermined significance (MGUS). In >5% of MGUS patients there is a second MGUS clone (biclonal gammopathy of undetermined significance; BGUS), yet, at myeloma diagnosis, presentation of biclonal gammopathy myeloma (BGMy) is considered less frequent, implying that myeloma eradicates coexisting MGUS. METHODS: In the largest study of its kind, we assessed BGMy frequency amongst 6399 newly diagnosed myeloma patients enrolled in recent UK clinical trials. RESULTS: Compared to expected prevalence (i.e., >5% of MGUS have BGUS), only 58 of 6399 (0.91%) newly diagnosed myeloma patients had BGMy, indicating myeloma typically eliminates coexistent MGUS. In these 58 BGMy cases, the MGUS plasma cell clone was greatly suppressed in size compared to typical levels observed in conventional MGUS; contrarily, the MGUS clone did not inhibit the myeloma plasma cell clone in BGMy. CONCLUSION: Myeloma eliminates the majority of competing MGUS, and when it does not, the MGUS clone is substantially reduced in size.
Citation
British journal of cancer, 2017, 117 (6), pp. 835 - 839
Source Title
Publisher
NATURE PUBLISHING GROUP
ISSN
0007-0920
eISSN
1532-1827
Collections
Research Team
Myeloma Group
Myeloma Group
Myeloma Group