Anti-angiogenic agents in the age of resistance to immune checkpoint inhibitors: Do they have a role in non-oncogene-addicted non-small cell lung cancer?
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Embargo End Date
ICR Authors
Authors
Popat, S
Grohé, C
Corral, J
Reck, M
Novello, S
Gottfried, M
Radonjic, D
Kaiser, R
Grohé, C
Corral, J
Reck, M
Novello, S
Gottfried, M
Radonjic, D
Kaiser, R
Document Type
Journal Article
Date
2020-06-01
Date Accepted
2020-04-09
Abstract
The introduction of licensed front-line immunotherapies has heralded a new era for the treatment of non-oncogene-addicted, advanced non-small cell lung cancer (NSCLC). Yet as with all evolutions in clinical management, changes in practice can outpace the availability of the clinical evidence needed to inform subsequent therapeutic decision making. At the time of writing, there is limited available evidence on the optimum therapeutic options after progression on immunotherapy. Further research is needed to define mechanisms of immunotherapy resistance in patients with advanced NSCLC, and to understand the implications for subsequent treatment response. Pending the availability of robust clinical data and proven therapeutic options to underpin an optimized therapeutic pathway after progression on immunotherapy, attention must turn to the potential utility of currently licensed agents and any available supporting clinical data in this setting. Within this context we review the mechanistic arguments and supporting evidence for the use of anti-angiogenic agents as a means of targeting immunosuppression within the tumor microenvironment. We consider whether VEGF inhibition may help to normalize the tumor vasculature and to address immunosuppression - reinstating, and potentially enhancing, the effect of subsequent therapies. We also highlight evidence needs and signpost ongoing trials that should enable current clinical opinion in this area to be replaced by robust, evidence-based guidance.
Citation
Lung Cancer, 2020, 144 pp. 76 - 84
Source Title
Lung Cancer
Publisher
ELSEVIER IRELAND LTD
ISSN
0169-5002
eISSN
1872-8332
1872-8332
1872-8332