Candidate gene association studies and risk of Hodgkin lymphoma: a systematic review and meta-analysis.
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ICR Authors
Authors
Sud, A
Hemminki, K
Houlston, RS
Hemminki, K
Houlston, RS
Document Type
Journal Article
Date
2017-03-01
Date Accepted
2015-04-13
Date Available
Abstract
To evaluate the contribution of association studies of candidate polymorphisms to inherited predisposition to Hodgkin lymphoma (HL), we conducted a systematic review and meta-analysis of published case-control studies. Of the variants examined more than once in candidate gene association studies, we identified 21 studies that reported on 12 polymorphic variants in 10 genes. Data were also extracted from a published genome wide association study to allow analysis of an additional 47 variants in a further 30 genes. Promising associations were seen in nine of the variants (p < 0.05). Given that the estimated false positive report probabilities (FPRPs) for all associations are high (i.e. FPRP > 0.2), these findings should be interpreted with caution. While studies of candidate polymorphisms may be an attractive means of identifying risk factors for HL, future studies should employ sample sizes adequately powered to identify variants having only modest effects on HL risk. Furthermore, because of aetiological heterogeneity within HL, stratification of genotyping according to age, tumour Epstein-Barr virus status and histology is essential. Copyright © 2015 John Wiley & Sons, Ltd.
Citation
Hematological oncology, 2017, 35 (1), pp. 34 - 50
DOI
Source Title
Publisher
WILEY
ISSN
0278-0232
eISSN
1099-1069
Collections
Research Team
Cancer Genomics