Checkpoints in TNF-Induced Cell Death: Implications in Inflammation and Cancer.
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Embargo End Date
ICR Authors
Authors
Annibaldi, A
Meier, P
Meier, P
Document Type
Journal Article
Date
2018-01-01
Date Accepted
2017-11-13
Abstract
Tumor necrosis factor (TNF) is a proinflammatory cytokine that coordinates tissue homeostasis by regulating cytokine production, cell survival, and cell death. However, how life and death decisions are made in response to TNF is poorly understood. Many inflammatory pathologies are now recognized to be driven by aberrant TNF-induced cell death, which, in most circumstances, depends on the kinase Receptor-interacting serine/threonine-protein kinase 1 (RIPK1). Recent advances have identified ubiquitin (Ub)-mediated phosphorylation of RIPK1 as belonging to crucial checkpoints for cell fate in inflammation and infection. A better understanding of these checkpoints might lead to new approaches for the treatment of chronic inflammatory diseases fueled by aberrant RIPK1-induced cell death, and/or reveal novel strategies for anticancer immunotherapies, harnessing the ability of RIPK1 to trigger immunogenic cell death.
Citation
Trends in molecular medicine, 2018, 24 (1), pp. 49 - 65
Source Title
Publisher
ELSEVIER SCI LTD
ISSN
1471-4914
eISSN
1471-499X
Collections
Research Team
Cell Death and Immunity