Investigating Low-Velocity Fluid Flow in Tumors with Convection-MRI.
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Embargo End Date
ICR Authors
Authors
Walker-Samuel, S
Roberts, TA
Ramasawmy, R
Burrell, JS
Johnson, SP
Siow, BM
Richardson, S
Gonçalves, MR
Pendse, D
Robinson, SP
Pedley, RB
Lythgoe, MF
Roberts, TA
Ramasawmy, R
Burrell, JS
Johnson, SP
Siow, BM
Richardson, S
Gonçalves, MR
Pendse, D
Robinson, SP
Pedley, RB
Lythgoe, MF
Document Type
Journal Article
Date
2018-04-01
Date Accepted
2018-01-05
Abstract
Several distinct fluid flow phenomena occur in solid tumors, including intravascular blood flow and interstitial convection. Interstitial fluid pressure is often raised in solid tumors, which can limit drug delivery. To probe low-velocity flow in tumors resulting from raised interstitial fluid pressure, we developed a novel MRI technique named convection-MRI, which uses a phase-contrast acquisition with a dual-inversion vascular nulling preparation to separate intra- and extravascular flow. Here, we report the results of experiments in flow phantoms, numerical simulations, and tumor xenograft models to investigate the technical feasibility of convection-MRI. We observed a significant correlation between estimates of effective fluid pressure from convection-MRI with gold-standard, invasive measurements of interstitial fluid pressure in mouse models of human colorectal carcinoma. Our results show how convection-MRI can provide insights into the growth and responsiveness to vascular-targeting therapy in colorectal cancers.Significance: A noninvasive method for measuring low-velocity fluid flow caused by raised fluid pressure can be used to assess changes caused by therapy. Cancer Res; 78(7); 1859-72. ©2018 AACR.
Citation
Cancer research, 2018, 78 (7), pp. 1859 - 1872
Source Title
Publisher
AMER ASSOC CANCER RESEARCH
ISSN
0008-5472
eISSN
1538-7445
Collections
Research Team
Pre-Clinical MRI