Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
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Authors
Michailidou, K
Hall, P
Gonzalez-Neira, A
Ghoussaini, M
Dennis, J
Milne, RL
Schmidt, MK
Chang-Claude, J
Bojesen, SE
Bolla, MK
Wang, Q
Dicks, E
Lee, A
Turnbull, C
Rahman, N
Breast and Ovarian Cancer Susceptibility Collaboration,
Fletcher, O
Peto, J
Gibson, L
Dos Santos Silva, I
Nevanlinna, H
Muranen, TA
Aittomäki, K
Blomqvist, C
Czene, K
Irwanto, A
Liu, J
Waisfisz, Q
Meijers-Heijboer, H
Adank, M
Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON),
van der Luijt, RB
Hein, R
Dahmen, N
Beckman, L
Meindl, A
Schmutzler, RK
Müller-Myhsok, B
Lichtner, P
Hopper, JL
Southey, MC
Makalic, E
Schmidt, DF
Uitterlinden, AG
Hofman, A
Hunter, DJ
Chanock, SJ
Vincent, D
Bacot, F
Tessier, DC
Canisius, S
Wessels, LFA
Haiman, CA
Shah, M
Luben, R
Brown, J
Luccarini, C
Schoof, N
Humphreys, K
Li, J
Nordestgaard, BG
Nielsen, SF
Flyger, H
Couch, FJ
Wang, X
Vachon, C
Stevens, KN
Lambrechts, D
Moisse, M
Paridaens, R
Christiaens, M-R
Rudolph, A
Nickels, S
Flesch-Janys, D
Johnson, N
Aitken, Z
Aaltonen, K
Heikkinen, T
Broeks, A
Veer, LJV
van der Schoot, CE
Guénel, P
Truong, T
Laurent-Puig, P
Menegaux, F
Marme, F
Schneeweiss, A
Sohn, C
Burwinkel, B
Zamora, MP
Perez, JIA
Pita, G
Alonso, MR
Cox, A
Brock, IW
Cross, SS
Reed, MWR
Sawyer, EJ
Tomlinson, I
Kerin, MJ
Miller, N
Henderson, BE
Schumacher, F
Le Marchand, L
Andrulis, IL
Knight, JA
Glendon, G
Mulligan, AM
kConFab Investigators,
Australian Ovarian Cancer Study Group,
Lindblom, A
Margolin, S
Hooning, MJ
Hollestelle, A
van den Ouweland, AMW
Jager, A
Bui, QM
Stone, J
Dite, GS
Apicella, C
Tsimiklis, H
Giles, GG
Severi, G
Baglietto, L
Fasching, PA
Haeberle, L
Ekici, AB
Beckmann, MW
Brenner, H
Müller, H
Arndt, V
Stegmaier, C
Swerdlow, A
Ashworth, A
Orr, N
Jones, M
Figueroa, J
Lissowska, J
Brinton, L
Goldberg, MS
Labrèche, F
Dumont, M
Winqvist, R
Pylkäs, K
Jukkola-Vuorinen, A
Grip, M
Brauch, H
Hamann, U
Brüning, T
GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network,
Radice, P
Peterlongo, P
Manoukian, S
Bonanni, B
Devilee, P
Tollenaar, RAEM
Seynaeve, C
van Asperen, CJ
Jakubowska, A
Lubinski, J
Jaworska, K
Durda, K
Mannermaa, A
Kataja, V
Kosma, V-M
Hartikainen, JM
Bogdanova, NV
Antonenkova, NN
Dörk, T
Kristensen, VN
Anton-Culver, H
Slager, S
Toland, AE
Edge, S
Fostira, F
Kang, D
Yoo, K-Y
Noh, D-Y
Matsuo, K
Ito, H
Iwata, H
Sueta, A
Wu, AH
Tseng, C-C
Van Den Berg, D
Stram, DO
Shu, X-O
Lu, W
Gao, Y-T
Cai, H
Teo, SH
Yip, CH
Phuah, SY
Cornes, BK
Hartman, M
Miao, H
Lim, WY
Sng, J-H
Muir, K
Lophatananon, A
Stewart-Brown, S
Siriwanarangsan, P
Shen, C-Y
Hsiung, C-N
Wu, P-E
Ding, S-L
Sangrajrang, S
Gaborieau, V
Brennan, P
McKay, J
Blot, WJ
Signorello, LB
Cai, Q
Zheng, W
Deming-Halverson, S
Shrubsole, M
Long, J
Simard, J
Garcia-Closas, M
Pharoah, PDP
Chenevix-Trench, G
Dunning, AM
Benitez, J
Easton, DF
Hall, P
Gonzalez-Neira, A
Ghoussaini, M
Dennis, J
Milne, RL
Schmidt, MK
Chang-Claude, J
Bojesen, SE
Bolla, MK
Wang, Q
Dicks, E
Lee, A
Turnbull, C
Rahman, N
Breast and Ovarian Cancer Susceptibility Collaboration,
Fletcher, O
Peto, J
Gibson, L
Dos Santos Silva, I
Nevanlinna, H
Muranen, TA
Aittomäki, K
Blomqvist, C
Czene, K
Irwanto, A
Liu, J
Waisfisz, Q
Meijers-Heijboer, H
Adank, M
Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON),
van der Luijt, RB
Hein, R
Dahmen, N
Beckman, L
Meindl, A
Schmutzler, RK
Müller-Myhsok, B
Lichtner, P
Hopper, JL
Southey, MC
Makalic, E
Schmidt, DF
Uitterlinden, AG
Hofman, A
Hunter, DJ
Chanock, SJ
Vincent, D
Bacot, F
Tessier, DC
Canisius, S
Wessels, LFA
Haiman, CA
Shah, M
Luben, R
Brown, J
Luccarini, C
Schoof, N
Humphreys, K
Li, J
Nordestgaard, BG
Nielsen, SF
Flyger, H
Couch, FJ
Wang, X
Vachon, C
Stevens, KN
Lambrechts, D
Moisse, M
Paridaens, R
Christiaens, M-R
Rudolph, A
Nickels, S
Flesch-Janys, D
Johnson, N
Aitken, Z
Aaltonen, K
Heikkinen, T
Broeks, A
Veer, LJV
van der Schoot, CE
Guénel, P
Truong, T
Laurent-Puig, P
Menegaux, F
Marme, F
Schneeweiss, A
Sohn, C
Burwinkel, B
Zamora, MP
Perez, JIA
Pita, G
Alonso, MR
Cox, A
Brock, IW
Cross, SS
Reed, MWR
Sawyer, EJ
Tomlinson, I
Kerin, MJ
Miller, N
Henderson, BE
Schumacher, F
Le Marchand, L
Andrulis, IL
Knight, JA
Glendon, G
Mulligan, AM
kConFab Investigators,
Australian Ovarian Cancer Study Group,
Lindblom, A
Margolin, S
Hooning, MJ
Hollestelle, A
van den Ouweland, AMW
Jager, A
Bui, QM
Stone, J
Dite, GS
Apicella, C
Tsimiklis, H
Giles, GG
Severi, G
Baglietto, L
Fasching, PA
Haeberle, L
Ekici, AB
Beckmann, MW
Brenner, H
Müller, H
Arndt, V
Stegmaier, C
Swerdlow, A
Ashworth, A
Orr, N
Jones, M
Figueroa, J
Lissowska, J
Brinton, L
Goldberg, MS
Labrèche, F
Dumont, M
Winqvist, R
Pylkäs, K
Jukkola-Vuorinen, A
Grip, M
Brauch, H
Hamann, U
Brüning, T
GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network,
Radice, P
Peterlongo, P
Manoukian, S
Bonanni, B
Devilee, P
Tollenaar, RAEM
Seynaeve, C
van Asperen, CJ
Jakubowska, A
Lubinski, J
Jaworska, K
Durda, K
Mannermaa, A
Kataja, V
Kosma, V-M
Hartikainen, JM
Bogdanova, NV
Antonenkova, NN
Dörk, T
Kristensen, VN
Anton-Culver, H
Slager, S
Toland, AE
Edge, S
Fostira, F
Kang, D
Yoo, K-Y
Noh, D-Y
Matsuo, K
Ito, H
Iwata, H
Sueta, A
Wu, AH
Tseng, C-C
Van Den Berg, D
Stram, DO
Shu, X-O
Lu, W
Gao, Y-T
Cai, H
Teo, SH
Yip, CH
Phuah, SY
Cornes, BK
Hartman, M
Miao, H
Lim, WY
Sng, J-H
Muir, K
Lophatananon, A
Stewart-Brown, S
Siriwanarangsan, P
Shen, C-Y
Hsiung, C-N
Wu, P-E
Ding, S-L
Sangrajrang, S
Gaborieau, V
Brennan, P
McKay, J
Blot, WJ
Signorello, LB
Cai, Q
Zheng, W
Deming-Halverson, S
Shrubsole, M
Long, J
Simard, J
Garcia-Closas, M
Pharoah, PDP
Chenevix-Trench, G
Dunning, AM
Benitez, J
Easton, DF
Document Type
Journal Article
Date
2013-04-01
Date Accepted
2013-01-30
Abstract
Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborative Oncological Gene-environment Study, COGS) and used a custom Illumina iSelect genotyping array, iCOGS, comprising more than 200,000 SNPs. We identified SNPs at 41 new breast cancer susceptibility loci at genome-wide significance (P < 5 × 10(-8)). Further analyses suggest that more than 1,000 additional loci are involved in breast cancer susceptibility.
Citation
Nature genetics, 2013, 45 (4), pp. 353 - 361e2
DOI
Source Title
Publisher
NATURE PUBLISHING GROUP
ISSN
1061-4036
eISSN
1546-1718
Research Team
Complex Trait Genetics
Functional Genetic Epidemiology
Molecular Epidemiology
Predisposition & Translation Genetics
Aetiological Epidemiology
Genetic Susceptibility
Gene Function
Functional Genetic Epidemiology
Molecular Epidemiology
Predisposition & Translation Genetics
Aetiological Epidemiology
Genetic Susceptibility
Gene Function