Mechanism and non-mechanism based imaging biomarkers for assessing biological response to treatment in non-small cell lung cancer.
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Authors
Weller, A
O'Brien, MER
Ahmed, M
Popat, S
Bhosle, J
McDonald, F
Yap, TA
Du, Y
Vlahos, I
deSouza, NM
O'Brien, MER
Ahmed, M
Popat, S
Bhosle, J
McDonald, F
Yap, TA
Du, Y
Vlahos, I
deSouza, NM
Document Type
Journal Article
Date
2016-05-01
Date Accepted
2016-02-18
Abstract
Therapeutic options in locally advanced non-small cell lung cancer (NSCLC) have expanded in the past decade to include a palate of targeted interventions such as high dose targeted thermal ablations, radiotherapy and growing platform of antibody and small molecule therapies and immunotherapies. Although these therapies have varied mechanisms of action, they often induce changes in tumour architecture and microenvironment such that response is not always accompanied by early reduction in tumour mass, and evaluation by criteria other than size is needed to report more effectively on response. Functional imaging techniques, which probe the tumour and its microenvironment through novel positron emission tomography and magnetic resonance imaging techniques, offer more detailed insights into and quantitation of tumour response than is available on anatomical imaging alone. Use of these biomarkers, or other rational combinations as readouts of pathological response in NSCLC have potential to provide more accurate predictors of treatment outcomes. In this article, the robustness of the more commonly available positron emission tomography and magnetic resonance imaging biomarker indices is examined and the evidence for their application in NSCLC is reviewed.
Citation
European journal of cancer (Oxford, England : 1990), 2016, 59 pp. 65 - 78
Rights
Source Title
Publisher
ELSEVIER SCI LTD
ISSN
0959-8049
eISSN
1879-0852
Research Team
Medicine Drug Development Unit (de Bono)
Thoracic Oncology
Treatment of thoracic tumours
Lung Radiotherapy
Magnetic Resonance
Thoracic Oncology
Treatment of thoracic tumours
Lung Radiotherapy
Magnetic Resonance