An emerging role for IQGAP1 in tight junction control.
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Embargo End Date
ICR Authors
Authors
Tanos, BE
Yeaman, C
Rodriguez-Boulan, E
Yeaman, C
Rodriguez-Boulan, E
Document Type
Journal Article
Date
2018-09
Date Accepted
Abstract
IQGAP1 is a scaffold protein involved in the assembly of adherens junctions. Our work has recently revealed a novel role for IQGAP1 in the regulation of tight junctions (TJ) through differential recruitment of claudins to the nascent TJ. Here, we discuss the potential mechanisms of this regulation, including IQGAP1 effects on CDC42, and IQGAP1 interactions with sorting/trafficking molecules (e.g. Exo70). Given the many roles of IQGAP1 and the large number of interacting partners, we focus our discussion of these functions in the context of junction formation, trafficking, growth factor signaling and cancer. We also propose a potential role for IQGAP1 in regulating epithelial integrity and compartmentalized signaling in epithelia.
Citation
Small GTPases, 2018, 9 (5), pp. 375 - 383
Source Title
Publisher
ISSN
2154-1248
eISSN
2154-1256