Cancer cell transmission via the placenta.
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Embargo End Date
ICR Authors
Authors
Greaves, M
Hughes, W
Hughes, W
Document Type
Journal Article
Date
2018-01-01
Date Accepted
2018-04-02
Abstract
Cancer cells have a parasitic propensity in the primary host but their capacity to transit between individuals is severely restrained by two factors: a lack of a route for viable cell transfer and immune recognition in allogeneic, secondary recipients. Several examples of transmissible animal cancers are now recognised. In humans, the only natural route for transmission is via the haemochorial placenta which is permissive for cell traffic. There are three special examples of this occurring in utero: maternal to foetus, intraplacental twin to twin leukaemias and choriocarcinoma-extra-embryonic cells to mother. We discuss the rare circumstances under which such transmission occurs.
Citation
Evolution, medicine, and public health, 2018, 2018 (1), pp. 106 - 115
Source Title
Publisher
OXFORD UNIV PRESS
ISSN
2050-6201
eISSN
2050-6201
Collections
Research Team
Biology of Childhood Leukaemia