Evaluation of DFO-HOPO as an octadentate chelator for zirconium-89.
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Embargo End Date
ICR Authors
Authors
Allott, L
Da Pieve, C
Meyers, J
Spinks, T
Ciobota, DM
Kramer-Marek, G
Smith, G
Da Pieve, C
Meyers, J
Spinks, T
Ciobota, DM
Kramer-Marek, G
Smith, G
Document Type
Journal Article
Date
2017-07-27
Date Accepted
2017-07-07
Abstract
The future of 89Zr-based immuno-PET is reliant upon the development of new chelators with improved stability compared to the currently used deferoxamine (DFO). Herein, we report the evaluation of the octadentate molecule DFO-HOPO (3) as a suitable chelator for 89Zr and a more stable alternative to DFO. The molecule showed good potential for the future development of a DFO-HOPO-based bifunctional chelator (BFC) for the radiolabelling of biomolecules with 89Zr. This work broadens the selection of available chelators for 89Zr in search of improved successors to DFO for clinical 89Zr-immuno-PET.
Citation
Chemical communications (Cambridge, England), 2017, 53 (61), pp. 8529 - 8532
Source Title
Publisher
ROYAL SOC CHEMISTRY
ISSN
1359-7345
eISSN
1364-548X
Research Team
Medicinal Chemistry 1
PET Radiochemistry
Preclinical Molecular Imaging
PET Radiochemistry
Preclinical Molecular Imaging