Choose and Use Your Chemical Probe Wisely to Explore Cancer Biology.
Embargo End Date
ICR Authors
Authors
Blagg, J
Workman, P
Workman, P
Document Type
Journal Article
Date
2017-07-10
Date Accepted
2017-06-09
Abstract
Small-molecule chemical probes or tools have become progressively more important in recent years as valuable reagents to investigate fundamental biological mechanisms and processes causing disease, including cancer. Chemical probes have also achieved greater prominence alongside complementary biological reagents for target validation in drug discovery. However, there is evidence of widespread continuing misuse and promulgation of poor-quality and insufficiently selective chemical probes, perpetuating a worrisome and misleading pollution of the scientific literature. We discuss current challenges with the selection and use of chemical probes, and suggest how biologists can and should be more discriminating in the probes they employ.
Citation
Cancer cell, 2017, 32 (1), pp. 9 - 25
Source Title
Publisher
CELL PRESS
ISSN
1535-6108
eISSN
1878-3686
Collections
Research Team
Medicinal Chemistry 1