DNA methylation-based classification of central nervous system tumours.
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ICR Authors
Authors
Capper, D
Jones, DTW
Sill, M
Hovestadt, V
Schrimpf, D
Sturm, D
Koelsche, C
Sahm, F
Chavez, L
Reuss, DE
Kratz, A
Wefers, AK
Huang, K
Pajtler, KW
Schweizer, L
Stichel, D
Olar, A
Engel, NW
Lindenberg, K
Harter, PN
Braczynski, AK
Plate, KH
Dohmen, H
Garvalov, BK
Coras, R
Hölsken, A
Hewer, E
Bewerunge-Hudler, M
Schick, M
Fischer, R
Beschorner, R
Schittenhelm, J
Staszewski, O
Wani, K
Varlet, P
Pages, M
Temming, P
Lohmann, D
Selt, F
Witt, H
Milde, T
Witt, O
Aronica, E
Giangaspero, F
Rushing, E
Scheurlen, W
Geisenberger, C
Rodriguez, FJ
Becker, A
Preusser, M
Haberler, C
Bjerkvig, R
Cryan, J
Farrell, M
Deckert, M
Hench, J
Frank, S
Serrano, J
Kannan, K
Tsirigos, A
Brück, W
Hofer, S
Brehmer, S
Seiz-Rosenhagen, M
Hänggi, D
Hans, V
Rozsnoki, S
Hansford, JR
Kohlhof, P
Kristensen, BW
Lechner, M
Lopes, B
Mawrin, C
Ketter, R
Kulozik, A
Khatib, Z
Heppner, F
Koch, A
Jouvet, A
Keohane, C
Mühleisen, H
Mueller, W
Pohl, U
Prinz, M
Benner, A
Zapatka, M
Gottardo, NG
Driever, PH
Kramm, CM
Müller, HL
Rutkowski, S
von Hoff, K
Frühwald, MC
Gnekow, A
Fleischhack, G
Tippelt, S
Calaminus, G
Monoranu, C-M
Perry, A
Jones, C
Jacques, TS
Radlwimmer, B
Gessi, M
Pietsch, T
Schramm, J
Schackert, G
Westphal, M
Reifenberger, G
Wesseling, P
Weller, M
Collins, VP
Blümcke, I
Bendszus, M
Debus, J
Huang, A
Jabado, N
Northcott, PA
Paulus, W
Gajjar, A
Robinson, GW
Taylor, MD
Jaunmuktane, Z
Ryzhova, M
Platten, M
Unterberg, A
Wick, W
Karajannis, MA
Mittelbronn, M
Acker, T
Hartmann, C
Aldape, K
Schüller, U
Buslei, R
Lichter, P
Kool, M
Herold-Mende, C
Ellison, DW
Hasselblatt, M
Snuderl, M
Brandner, S
Korshunov, A
von Deimling, A
Pfister, SM
Jones, DTW
Sill, M
Hovestadt, V
Schrimpf, D
Sturm, D
Koelsche, C
Sahm, F
Chavez, L
Reuss, DE
Kratz, A
Wefers, AK
Huang, K
Pajtler, KW
Schweizer, L
Stichel, D
Olar, A
Engel, NW
Lindenberg, K
Harter, PN
Braczynski, AK
Plate, KH
Dohmen, H
Garvalov, BK
Coras, R
Hölsken, A
Hewer, E
Bewerunge-Hudler, M
Schick, M
Fischer, R
Beschorner, R
Schittenhelm, J
Staszewski, O
Wani, K
Varlet, P
Pages, M
Temming, P
Lohmann, D
Selt, F
Witt, H
Milde, T
Witt, O
Aronica, E
Giangaspero, F
Rushing, E
Scheurlen, W
Geisenberger, C
Rodriguez, FJ
Becker, A
Preusser, M
Haberler, C
Bjerkvig, R
Cryan, J
Farrell, M
Deckert, M
Hench, J
Frank, S
Serrano, J
Kannan, K
Tsirigos, A
Brück, W
Hofer, S
Brehmer, S
Seiz-Rosenhagen, M
Hänggi, D
Hans, V
Rozsnoki, S
Hansford, JR
Kohlhof, P
Kristensen, BW
Lechner, M
Lopes, B
Mawrin, C
Ketter, R
Kulozik, A
Khatib, Z
Heppner, F
Koch, A
Jouvet, A
Keohane, C
Mühleisen, H
Mueller, W
Pohl, U
Prinz, M
Benner, A
Zapatka, M
Gottardo, NG
Driever, PH
Kramm, CM
Müller, HL
Rutkowski, S
von Hoff, K
Frühwald, MC
Gnekow, A
Fleischhack, G
Tippelt, S
Calaminus, G
Monoranu, C-M
Perry, A
Jones, C
Jacques, TS
Radlwimmer, B
Gessi, M
Pietsch, T
Schramm, J
Schackert, G
Westphal, M
Reifenberger, G
Wesseling, P
Weller, M
Collins, VP
Blümcke, I
Bendszus, M
Debus, J
Huang, A
Jabado, N
Northcott, PA
Paulus, W
Gajjar, A
Robinson, GW
Taylor, MD
Jaunmuktane, Z
Ryzhova, M
Platten, M
Unterberg, A
Wick, W
Karajannis, MA
Mittelbronn, M
Acker, T
Hartmann, C
Aldape, K
Schüller, U
Buslei, R
Lichter, P
Kool, M
Herold-Mende, C
Ellison, DW
Hasselblatt, M
Snuderl, M
Brandner, S
Korshunov, A
von Deimling, A
Pfister, SM
Document Type
Journal Article
Date
2018-03-22
Date Accepted
2018-02-13
Abstract
Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-with substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology.
Citation
Nature, 2018, 555 (7697), pp. 469 - 474
Source Title
Publisher
NATURE PORTFOLIO
ISSN
0028-0836
eISSN
1476-4687
Collections
Research Team
Glioma Team