RNA polymerase I, bending the rules?
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Embargo End Date
ICR Authors
Authors
Jochem, L
Ramsay, EP
Vannini, A
Ramsay, EP
Vannini, A
Document Type
Journal Article
Date
2017-09-15
Date Accepted
Abstract
Transcription initiation is one of the key regulatory steps in expressing the genetic information encoded in the DNA. Mechanisms of RNA Pol II transcription have been extensively studied, whereas the structural basis of RNA Pol I and III transcription is still poorly defined. Three recent studies discussed here give a first glimpse into the molecular mechanisms underlying the process of RNA Pol I transcriptional initiation and reveal unexpected structural differences compared to the previously described homologous Pol II structures.
Citation
The EMBO journal, 2017, 36 (18), pp. 2664 - 2666
Source Title
Publisher
WILEY
ISSN
0261-4189
eISSN
1460-2075
Collections
Research Team
Vannini Group