The Emerging Role of PET/CT with PSMA-Targeting Radiopharmaceuticals in Clear Cell Renal Cancer: An Updated Systematic Review.
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Embargo End Date
ICR Authors
Authors
Rizzo, A
Racca, M
Dall'Armellina, S
Rescigno, P
Banna, GL
Albano, D
Dondi, F
Bertagna, F
Annunziata, S
Treglia, G
Racca, M
Dall'Armellina, S
Rescigno, P
Banna, GL
Albano, D
Dondi, F
Bertagna, F
Annunziata, S
Treglia, G
Document Type
Journal Article
Date
2023-01-05
Date Accepted
2023-01-03
Abstract
BACKGROUND: Recent articles proposed the employment of positron emission tomography/computed tomography (PET/CT) with prostate-specific membrane antigen (PSMA)-targeting radiopharmaceuticals in clear cell renal cell carcinoma (ccRCC). METHODS: The authors performed a comprehensive literature search of studies on the performance of PET/CT with PSMA-targeting radiopharmaceuticals in ccRCC. Original articles concerning this imaging examination were included in newly diagnosed ccRCC patients and ccRCC patients with disease recurrence. RESULTS: A total of sixteen papers concerning the diagnostic performance of PSMA-targeted PET/CT in ccRCC (331 patients) were included in this systematic review. The included articles demonstrated an excellent detection rate of PSMA-targeting PET/CT in ccRCC. CONCLUSIONS: PSMA-targeted PET/CT seems promising in detecting ccRCC lesions as well as in discriminating the presence of aggressive phenotypes. Prospective multicentric studies are warranted to strengthen the role of PSMA-targeting PET/CT in ccRCC.
Citation
Cancers, 2023, 15 (2), pp. 355 -
Source Title
Cancers
Publisher
MDPI
ISSN
2072-6694
eISSN
2072-6694
2072-6694
2072-6694
Collections
Research Team
PrCa Targeted Therapy