First-line PARP inhibitors in ovarian cancer: summary of an ESMO Open - Cancer Horizons round-table discussion.
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Embargo End Date
ICR Authors
Authors
Banerjee, S
Gonzalez-Martin, A
Harter, P
Lorusso, D
Moore, KN
Oaknin, A
Ray-Coquard, I
Gonzalez-Martin, A
Harter, P
Lorusso, D
Moore, KN
Oaknin, A
Ray-Coquard, I
Document Type
Journal Article
Date
2020-11-01
Date Accepted
2020-11-25
Abstract
Poly(ADP-ribose) polymerase (PARP) inhibitor maintenance therapy is the latest breakthrough in the management of newly diagnosed advanced ovarian cancer. The results of the SOLO-1 trial in 2018 led to European Medicines Agency and Food and Drug Administration approval of olaparib as first-line maintenance therapy in patients with BRCA1/2 mutation, establishing a new standard of care. Subsequently, the results of three phase III trials (PRIMA, PAOLA-1, VELIA) evaluating the use of first-line PARP inhibitors beyond patients with BRCA1/2 mutations and as combination strategies were presented in 2019, leading to the recent approval of maintenance niraparib irrespective of biomarker status and olaparib in combination with bevacizumab in homologous recombination deficiency-positive-associated advanced ovarian cancer. An ESMO Open - Cancer Horizons round-table expert panel discussed the four phase III trials of first-line PARP inhibitor therapy and how they are changing the clinical management of advanced ovarian cancer.
Citation
ESMO open, 2020, 5 (6)
Source Title
Publisher
ELSEVIER
ISSN
2059-7029
eISSN
2059-7029