Is There a Special Role for Ovarian Hormones in the Pathogenesis of Lobular Carcinoma?
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Embargo End Date
ICR Authors
Authors
Flaherty, RL
Sflomos, G
Brisken, C
Sflomos, G
Brisken, C
Document Type
Journal Article
Date
2024-03-29
Date Accepted
2024-03-29
Abstract
Lobular carcinoma represent the most common special histological subtype of breast cancer, with the majority classed as hormone receptor positive. Rates of invasive lobular carcinoma in postmenopausal women have been seen to increase globally, while other hormone receptor-positive breast cancers proportionally have not followed the same trend. This has been linked to exposure to exogenous ovarian hormones such as hormone replacement therapy. Reproductive factors resulting in increased lifetime exposure to endogenous ovarian hormones have also been linked to an increased risk of lobular breast cancer, and taken together, these data make a case for the role of ovarian hormones in the genesis and progression of the disease. In this review, we summarize current understanding of the epidemiological associations between ovarian hormones and lobular breast cancer and highlight mechanistic links that may underpin the etiology and biology.
Citation
Endocrinology, 2024, 165 (5), pp. bqae031 -
Source Title
Endocrinology
Publisher
ENDOCRINE SOC
ISSN
0013-7227
eISSN
1945-7170
1945-7170
1945-7170
Collections
Research Team
Endocrine control mechans