The next wave of interactomics: Mapping the SLiM-based interactions of the intrinsically disordered proteome.
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Embargo End Date
ICR Authors
Authors
Davey, NE
Simonetti, L
Ivarsson, Y
Simonetti, L
Ivarsson, Y
Document Type
Journal Article
Date
2023-06-01
Date Accepted
2023-03-17
Abstract
Short linear motifs (SLiMs) are a unique and ubiquitous class of protein interaction modules that perform key regulatory functions and drive dynamic complex formation. For decades, interactions mediated by SLiMs have accumulated through detailed low-throughput experiments. Recent methodological advances have opened this previously underexplored area of the human interactome to high-throughput protein-protein interaction discovery. In this article, we discuss that SLiM-based interactions represent a significant blind spot in the current interactomics data, introduce the key methods that are illuminating the elusive SLiM-mediated interactome of the human cell on a large scale, and discuss the implications for the field.
Citation
Current Opinion in Structural Biology, 2023, 80 pp. 102593 -
Source Title
Current Opinion in Structural Biology
Publisher
CURRENT BIOLOGY LTD
ISSN
0959-440X
eISSN
1879-033X
1879-033X
1879-033X
Collections
Research Team
Short Linear Motif