The Diagnostic Accuracy of 18 F-FGD-PET/CT for Cancer of the Gallbladder: A Retrospective Study.
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Embargo End Date
ICR Authors
Authors
Pericleous, S
Doran, SLF
Wotherspoon, A
Terlizzo, M
Riddell, A
Brown, G
Shur, J
Chua, S
Hujairi, N
Middleton, N
Cunningham, D
Kumar, S
Bhogal, RH
Doran, SLF
Wotherspoon, A
Terlizzo, M
Riddell, A
Brown, G
Shur, J
Chua, S
Hujairi, N
Middleton, N
Cunningham, D
Kumar, S
Bhogal, RH
Document Type
Journal Article
Date
2022-06-01
Date Accepted
2022-06-01
Abstract
Background Gallbladder cancer has a poor prognosis and imaging can have variable diagnostic accuracy. We assessed the ability of preoperative 18 F-fluorodeoxyglucose positron emission tomography computed tomography ( 18 F-FDG-PET/CT) imaging to predict a postoperative histological diagnosis of gallbladder cancer. Method A retrospective analysis was undertaken in a cohort of patients, who had suspected gallbladder cancer on cross-sectional imaging and that underwent preoperative FDG-PET/CT scan. The discriminatory power of FDG-PET/CT was determined in receiver operator characteristic (ROC) analysis and diagnostic accuracy parameters were estimated at different thresholds of maximum standard unit value (SUV max ) . Results Twenty-two patients were included in the study; 7 had malignant and 15 benign diagnoses. There was no statistically significant difference between the measured SUV max between the two groups ( p = 0.71). With an area under the curve of 0.486, the ROC curve did not indicate any discriminatory power of FDG-PET/CT at any potential threshold of SUV max. Conclusion This study indicates that the diagnosis of primary gallbladder cancer cannot be accurately confirmed with FDG PET/CT scanning.
Citation
World Journal of Nuclear Medicine, 2022, 21 (2), pp. 112 - 119
Source Title
World Journal of Nuclear Medicine
Publisher
THIEME MEDICAL PUBL INC
ISSN
1450-1147
eISSN
1607-3312
1607-3312
1607-3312
Collections
Research Team
Medicine (RMH)