Non-Coding RNAs and Resistance to Anticancer Drugs in Gastrointestinal Tumors.
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ICR Authors
Authors
Hahne, JC
Valeri, N
Valeri, N
Document Type
Journal Article
Date
2018-06-18
Date Accepted
2018-05-31
Abstract
Non-coding RNAs are important regulators of gene expression and transcription. It is well established that impaired non-coding RNA expression especially the one of long non-coding RNAs and microRNAs is involved in a number of pathological conditions including cancer. Non-coding RNAs are responsible for the development of resistance to anticancer treatments as they regulate drug resistance-related genes, affect intracellular drug concentrations, induce alternative signaling pathways, alter drug efficiency via blocking cell cycle regulation, and DNA damage response. Furthermore, they can prevent therapeutic-induced cell death and promote epithelial-mesenchymal transition (EMT) and elicit non-cell autonomous mechanisms of resistance. In this review, we summarize the role of non-coding RNAs for different mechanisms resulting in drug resistance (e.g., drug transport, drug metabolism, cell cycle regulation, regulation of apoptotic pathways, cancer stem cells, and EMT) in the context of gastrointestinal cancers.
Citation
Frontiers in oncology, 2018, 8 pp. 226 - ?
Source Title
Publisher
FRONTIERS MEDIA SA
ISSN
2234-943X
eISSN
2234-943X
Collections
Research Team
Gastrointestinal Cancer Biology and Genomics