Infertility and risk of breast cancer in men: a national case-control study in England and Wales.
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Embargo End Date
ICR Authors
Authors
Swerdlow, AJ
Bruce, C
Cooke, R
Coulson, P
Jones, ME
Bruce, C
Cooke, R
Coulson, P
Jones, ME
Document Type
Journal Article
Date
2022-05-17
Date Accepted
2022-03-07
Abstract
PURPOSE: Breast cancer is uncommon in men and its aetiology is largely unknown, reflecting the limited size of studies thus far conducted. In general, number of children fathered has been found a risk factor inconsistently, and infertility not. We therefore investigated in a case-control study, the relation of risk of breast cancer in men to infertility and number of children. PATIENTS AND METHODS: We conducted a national case-control study in England and Wales, interviewing 1998 cases incident 2005-17 and 1597 male controls, which included questions on infertility and offspring. RESULTS: Risk of breast cancer was statistically significantly associated with male-origin infertility (OR = 2.03 (95% confidence interval (CI) 1.18-3.49)) but not if a couple's infertility had been diagnosed as of origin from the female partner (OR = 0.86 (0.51-1.45)). Risk was statistically significantly raised for men who had not fathered any children (OR = 1.50 (95% CI 1.21-1.86)) compared with men who were fathers. These associations were statistically significantly present for invasive tumours but not statistically significant for in situ tumours. CONCLUSION: Our data give strong evidence that risk of breast cancer is increased for men who are infertile. The reason is not clear and needs investigation.
Citation
Breast Cancer Research, 2022, 24 (1), pp. 29 -
Source Title
Breast Cancer Research
Publisher
BMC
ISSN
1465-5411
eISSN
1465-542X
1465-542X
1465-542X
Collections
Research Team
Aetiological Epidemiology